Mechanochemical Delivery and Dynamic Tracking of Fluorescent Quantum Dots in the Cytoplasm and Nucleus of Living Cells Export

@article{citeulike:4584765, abstract = {Studying molecular dynamics inside living cells is a major but highly rewarding challenge in cell biology. We present a nanoscale mechanochemical method to deliver fluorescent quantum dots (QDs) into living cells, using a membrane-penetrating nanoneedle. We demonstrate the selective delivery of monodispersed QDs into the cytoplasm and the nucleus of living cells and the tracking of the delivered QDs inside the cells. The ability to deliver and track QDs may invite unconventional strategies for studying biological processes and biophysical properties in living cells with spatial and temporal precision, potentially with molecular resolution.}, author = {Yum, Kyungsuk and Na, Sungsoo and Xiang, Yang and Wang, Ning and Yu, Min-Feng}, citeulike-article-id = {4584765}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/nl901047u}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/nl901047u}, doi = {10.1021/nl901047u}, journal = {Nano Letters}, keywords = {biophysics, qd, tracking-diffusion}, month = {May}, number = {5}, pages = {2193--2198}, posted-at = {2009-06-05 05:35:17}, priority = {2}, title = {Mechanochemical Delivery and Dynamic Tracking of Fluorescent Quantum Dots in the Cytoplasm and Nucleus of Living Cells}, url = {http://dx.doi.org/10.1021/nl901047u}, volume = {9}, year = {2009} }

TY - JOUR ID - citeulike:4584765 L3 - citeulike-article-id:4584765 N2 - Studying molecular dynamics inside living cells is a major but highly rewarding challenge in cell biology. We present a nanoscale mechanochemical method to deliver fluorescent quantum dots (QDs) into living cells, using a membrane-penetrating nanoneedle. We demonstrate the selective delivery of monodispersed QDs into the cytoplasm and the nucleus of living cells and the tracking of the delivered QDs inside the cells. The ability to deliver and track QDs may invite unconventional strategies for studying biological processes and biophysical properties in living cells with spatial and temporal precision, potentially with molecular resolution. IS - 5 JF - Nano Letters EP - 2198 TI - Mechanochemical Delivery and Dynamic Tracking of Fluorescent Quantum Dots in the Cytoplasm and Nucleus of Living Cells VL - 9 SP - 2193 KW - biophysics KW - qd KW - tracking-diffusion AU - Yum, Kyungsuk AU - Na, Sungsoo AU - Xiang, Yang AU - Wang, Ning AU - Yu, Min-Feng PY - 2009/05/13/ UR - http://dx.doi.org/10.1021/nl901047u ER -