Deforming DNA: From Physics to Biology Export

@article{citeulike:4753713, abstract = {The DNA double helix has become a modern icon which symbolizes our understanding of the molecular basis of life. It is less widely recognized that the double helix proposed by Watson and Crick more than half a century ago is a remarkably adaptable molecule that can undergo major conformational rearrangements without being irreversibly damaged. Indeed, DNA deformation is an intrinsic feature of many of the biological processes in which it is involved. Over the last two decades, single-molecule experiments coupled with molecular modeling have transformed our understanding of DNA flexibility, while the accumulation of high-resolution structures of DNA-protein complexes have demonstrated how organisms can exploit this property as a useful feature for preserving, reading, replicating, and packaging the genetic message. In this Minireview we summarize the information now available on the extreme - and the less extreme - deformations of the double helix.}, address = {Laboratoire de Biochimie Th\'{e}orique - UPR 9080 CNRS, Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, F-75005 Paris (France), Fax: (+33) 1-58-41-50-26; Unit\'{e} de Recherche Biotechnologie-Biocatalyse-Bioregulation, UMR 6204 CNRS \& Universit\'{e} de Nantes, Facult\'{e} des Sciences et Technologies, F-44322 Nantes Cedex 3 (France); Institut de Biologie et de Chimie des Prot\'{e}ines - UMR 5086 CNRS, Universit\'{e} de Lyon 7, passage du Vercors, F-69367 Lyon cedex 7 (France)}, author = {Pr\'{e}vost, Chantal and Takahashi, Masayuki and Lavery, Richard}, citeulike-article-id = {4753713}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/cphc.200900253}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/122421806/ABSTRACT}, doi = {10.1002/cphc.200900253}, journal = {ChemPhysChem}, keywords = {dna, review}, number = {9999}, pages = {NA+}, posted-at = {2009-06-05 17:08:57}, priority = {2}, title = {Deforming DNA: From Physics to Biology}, url = {http://dx.doi.org/10.1002/cphc.200900253}, volume = {9999}, year = {2009} }

TY - JOUR ID - citeulike:4753713 L3 - citeulike-article-id:4753713 N2 - The DNA double helix has become a modern icon which symbolizes our understanding of the molecular basis of life. It is less widely recognized that the double helix proposed by Watson and Crick more than half a century ago is a remarkably adaptable molecule that can undergo major conformational rearrangements without being irreversibly damaged. Indeed, DNA deformation is an intrinsic feature of many of the biological processes in which it is involved. Over the last two decades, single-molecule experiments coupled with molecular modeling have transformed our understanding of DNA flexibility, while the accumulation of high-resolution structures of DNA-protein complexes have demonstrated how organisms can exploit this property as a useful feature for preserving, reading, replicating, and packaging the genetic message. In this Minireview we summarize the information now available on the extreme - and the less extreme - deformations of the double helix. IS - 9999 JF - ChemPhysChem AD - Laboratoire de Biochimie Théorique - UPR 9080 CNRS, Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, F-75005 Paris (France), Fax: (+33) 1-58-41-50-26; Unité de Recherche Biotechnologie-Biocatalyse-Bioregulation, UMR 6204 CNRS & Université de Nantes, Faculté des Sciences et Technologies, F-44322 Nantes Cedex 3 (France); Institut de Biologie et de Chimie des Protéines - UMR 5086 CNRS, Université de Lyon 7, passage du Vercors, F-69367 Lyon cedex 7 (France) TI - Deforming DNA: From Physics to Biology VL - 9999 SP - NA KW - dna KW - review AU - Prévost, Chantal AU - Takahashi, Masayuki AU - Lavery, Richard PY - 2009/// UR - http://dx.doi.org/10.1002/cphc.200900253 ER -