Interventions for preventing or treating alcohol hangover: systematic review of randomised controlled trials Export

@article{citeulike:4920539, abstract = {Objective To assess the clinical evidence on the effectiveness of any medical intervention for preventing or treating alcohol hangover. Data sources Systematic searches on Medline, Embase, Amed, Cochrane Central, the National Research Register (UK), and ClincalTrials.gov (USA); hand searches of conference proceedings and bibliographies; contact with experts and manufacturers of commercial preparations. Language of publication was not restricted. Study selection and data extraction All randomised controlled trials of any medical intervention for preventing or treating alcohol hangover were included. Trials were considered if they were placebo controlled or controlled against a comparator intervention. Titles and abstracts of identified articles were read and hard copies were obtained. The selection of studies, data extraction, and validation were done independently by two reviewers. The Jadad score was used to evaluate methodological quality. Results Fifteen potentially relevant trials were identified. Seven publications failed to meet all inclusion criteria. Eight randomised controlled trials assessing eight different interventions were reviewed. The agents tested were propranolol, tropisetron, tolfenamic acid, fructose or glucose, and the dietary supplements Borago officinalis (borage), Cynara scolymus (artichoke), Opuntia ficus-indica (prickly pear), and a yeast based preparation. All studies were double blind. Significant intergroup differences for overall symptom scores and individual symptoms were reported only for tolfenamic acid, {gamma} linolenic acid from B officinalis, and a yeast based preparation. Conclusion No compelling evidence exists to suggest that any conventional or complementary intervention is effective for preventing or treating alcohol hangover. The most effective way to avoid the symptoms of alcohol induced hangover is to practise abstinence or moderation. 10.1136/bmj.331.7531.1515}, author = {Pittler, Max H. and Verster, Joris C. and Ernst, Edzard}, citeulike-article-id = {4920539}, citeulike-linkout-0 = {http://dx.doi.org/10.1136/bmj.331.7531.1515}, citeulike-linkout-1 = {http://www.bmj.com/cgi/content/abstract/331/7531/1515}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16373736}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16373736}, doi = {10.1136/bmj.331.7531.1515}, journal = {BMJ}, keywords = {fun}, month = {December}, number = {7531}, pages = {1515--1518}, posted-at = {2009-06-21 23:02:22}, priority = {2}, title = {Interventions for preventing or treating alcohol hangover: systematic review of randomised controlled trials}, url = {http://dx.doi.org/10.1136/bmj.331.7531.1515}, volume = {331}, year = {2005} }

TY - JOUR ID - citeulike:4920539 L3 - citeulike-article-id:4920539 N2 - Objective To assess the clinical evidence on the effectiveness of any medical intervention for preventing or treating alcohol hangover. Data sources Systematic searches on Medline, Embase, Amed, Cochrane Central, the National Research Register (UK), and ClincalTrials.gov (USA); hand searches of conference proceedings and bibliographies; contact with experts and manufacturers of commercial preparations. Language of publication was not restricted. Study selection and data extraction All randomised controlled trials of any medical intervention for preventing or treating alcohol hangover were included. Trials were considered if they were placebo controlled or controlled against a comparator intervention. Titles and abstracts of identified articles were read and hard copies were obtained. The selection of studies, data extraction, and validation were done independently by two reviewers. The Jadad score was used to evaluate methodological quality. Results Fifteen potentially relevant trials were identified. Seven publications failed to meet all inclusion criteria. Eight randomised controlled trials assessing eight different interventions were reviewed. The agents tested were propranolol, tropisetron, tolfenamic acid, fructose or glucose, and the dietary supplements Borago officinalis (borage), Cynara scolymus (artichoke), Opuntia ficus-indica (prickly pear), and a yeast based preparation. All studies were double blind. Significant intergroup differences for overall symptom scores and individual symptoms were reported only for tolfenamic acid, {gamma} linolenic acid from B officinalis, and a yeast based preparation. Conclusion No compelling evidence exists to suggest that any conventional or complementary intervention is effective for preventing or treating alcohol hangover. The most effective way to avoid the symptoms of alcohol induced hangover is to practise abstinence or moderation. 10.1136/bmj.331.7531.1515 IS - 7531 JF - BMJ EP - 1518 TI - Interventions for preventing or treating alcohol hangover: systematic review of randomised controlled trials VL - 331 SP - 1515 KW - fun AU - Pittler, Max AU - Verster, Joris AU - Ernst, Edzard PY - 2005/12/24/ UR - http://dx.doi.org/10.1136/bmj.331.7531.1515 ER -