Capturing the nanoscale complexity of cellular membranes in supported lipid bilayers Export

@article{citeulike:5313829, abstract = {The lateral mobility of cell membranes plays an important role in cell signaling, governing the rate at which embedded proteins can interact with other biomolecules. The past two decades have seen a dramatic transformation in understanding of this environment, as the mechanisms and potential implications of nanoscale structure of these systems has become accessible to theoretical and experimental investigation. In particular, emerging micro- and nano-scale fabrication techniques have made possible the direct manipulation of model membranes at the scales relevant to these biological processes. This review focuses on recent advances in nanopatterning of supported lipid bilayers, capturing the impact of membrane nanostructure on molecular diffusion and providing a powerful platform for further investigation of the role of this spatial complexity on cell signaling.}, author = {Kam, Lance C.}, citeulike-article-id = {5313829}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jsb.2009.05.006}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1047847709001397}, day = {12}, doi = {10.1016/j.jsb.2009.05.006}, issn = {10478477}, journal = {Journal of Structural Biology}, keywords = {membrane, supported-bilayer, tracking-diffusion}, month = {October}, number = {1}, pages = {3--10}, posted-at = {2009-10-29 06:53:51}, priority = {2}, title = {Capturing the nanoscale complexity of cellular membranes in supported lipid bilayers}, url = {http://dx.doi.org/10.1016/j.jsb.2009.05.006}, volume = {168}, year = {2009} }

TY - JOUR ID - citeulike:5313829 L3 - citeulike-article-id:5313829 N2 - The lateral mobility of cell membranes plays an important role in cell signaling, governing the rate at which embedded proteins can interact with other biomolecules. The past two decades have seen a dramatic transformation in understanding of this environment, as the mechanisms and potential implications of nanoscale structure of these systems has become accessible to theoretical and experimental investigation. In particular, emerging micro- and nano-scale fabrication techniques have made possible the direct manipulation of model membranes at the scales relevant to these biological processes. This review focuses on recent advances in nanopatterning of supported lipid bilayers, capturing the impact of membrane nanostructure on molecular diffusion and providing a powerful platform for further investigation of the role of this spatial complexity on cell signaling. IS - 1 JF - Journal of Structural Biology SN - 10478477 EP - 10 TI - Capturing the nanoscale complexity of cellular membranes in supported lipid bilayers VL - 168 SP - 3 KW - membrane KW - supported-bilayer KW - tracking-diffusion AU - Kam, Lance PY - 2009/10/12/ UR - http://dx.doi.org/10.1016/j.jsb.2009.05.006 ER -