Proton magnetic resonance spectroscopy of pediatric brain tumors Export

@article{citeulike:1477470, abstract = {1H MAGNETIC RESONANCE spectroscopy allows the regional quantitation of a number of metabolites from the brain in a noninvasive fashion. Spectra were obtained from 5 normal children and 25 children with brain tumors. Choline (Cho), N-acetylaspartate (NAA), creatine and phosphocreatine, and lactate were quantitated in the form of ratios. The brains of normal children showed relatively high concentrations of Cho and NAA and virtually no lactate, as has been shown in adults. Benign astrocytomas and ependymomas were characterized by an elevation of the Cho:NAA ratio and an abnormal accumulation of lactate. Intrinsic malignant tumors were remarkable for an even higher Cho:NAA ratio but had no more lactate than was found in the benign tumors. Proton magnetic resonance spectroscopy may prove useful in characterizing neoplastic tissue in conjunction with more conventional imaging modalities.}, address = {Division of Neurosurgery, Children's Hospital of Philadelphia, 34th Street and Civic Center Blvd., Philadelphia, PA 19104, United States}, author = {Sutton, L. N. and Wang, Z. and Gusnard, D. and Lange, B. and Perilongo, G. and Bogdan, A. R. and Detre, J. A. and Rorke, L. and Zimmerman, R. A.}, citeulike-article-id = {1477470}, citeulike-linkout-0 = {http://www.scopus.com/record/display.url?view=extended&origin=resultslist&eid=2-s2.0-0026768416}, journal = {NEUROSURGERY}, keywords = {brain, cancer, childhood-glioma, clinical-study, lactate, mrs, nmr, oxidative-metabolism, uncontrolled-proliferation, warburg}, number = {2}, pages = {195--202}, posted-at = {2007-07-24 21:31:26}, priority = {2}, title = {Proton magnetic resonance spectroscopy of pediatric brain tumors}, url = {http://www.scopus.com/record/display.url?view=extended&origin=resultslist&eid=2-s2.0-0026768416}, volume = {31}, year = {1992} }

TY - JOUR ID - citeulike:1477470 L3 - citeulike-article-id:1477470 N2 - 1H MAGNETIC RESONANCE spectroscopy allows the regional quantitation of a number of metabolites from the brain in a noninvasive fashion. Spectra were obtained from 5 normal children and 25 children with brain tumors. Choline (Cho), N-acetylaspartate (NAA), creatine and phosphocreatine, and lactate were quantitated in the form of ratios. The brains of normal children showed relatively high concentrations of Cho and NAA and virtually no lactate, as has been shown in adults. Benign astrocytomas and ependymomas were characterized by an elevation of the Cho:NAA ratio and an abnormal accumulation of lactate. Intrinsic malignant tumors were remarkable for an even higher Cho:NAA ratio but had no more lactate than was found in the benign tumors. Proton magnetic resonance spectroscopy may prove useful in characterizing neoplastic tissue in conjunction with more conventional imaging modalities. IS - 2 JF - NEUROSURGERY AD - Division of Neurosurgery, Children's Hospital of Philadelphia, 34th Street and Civic Center Blvd., Philadelphia, PA 19104, United States EP - 202 TI - Proton magnetic resonance spectroscopy of pediatric brain tumors VL - 31 SP - 195 KW - brain KW - cancer KW - childhood-glioma KW - clinical-study KW - lactate KW - mrs KW - nmr KW - oxidative-metabolism KW - uncontrolled-proliferation KW - warburg AU - Sutton, LN AU - Wang, Z AU - Gusnard, D AU - Lange, B AU - Perilongo, G AU - Bogdan, AR AU - Detre, JA AU - Rorke, L AU - Zimmerman, RA PY - 1992/// UR - http://www.scopus.com/record/display.url?view=extended&origin=resultslist&eid=2-s2.0-0026768416 ER -