Localized proton NMR observation of [3-13C]lactate in stroke after [1-13C]glucose infusion Export

@article{citeulike:2757877, abstract = {To assess whether elevated lactate in stable stroke is being actively produced from blood glucose localized 1H NMR stimulated echo spectra were obtained from a patient in the region of a 32-day-old cortical infarct before and 60-100 min after infusion of [1-13C]glucose. Prior to the infusion the spectrum from the region of the infarct contained an elevated resonance from C3 lactate and a greatly reduced resonance from N-acetyl groups relative to an unaffected contralateral region. After the infusion two additional resonances were observed at 62 and -64 Hz relative to the unlabeled resonance of C3 lactate which were assigned on the basis of chemical shift and relative intensity to [3-13C]lactate. The [3-13C]lactate fractional enrichment in the infarct region was measured to be 32\% which is within error one-half the average [1-13C]plasma glucose enrichment during the postinfusion NMR measurement. The result suggests that the stroke lactate pool was completely derived from infused glucose.}, author = {Rothman, D. L. and Howseman, A. M. and Graham, G. D. and Petroff, O. A. C. and Lantos, G. and Fayad, P. B. and Brass, L. M. and Shulman, G. I. and Shulman, R. G. and Prichard, J. W.}, citeulike-article-id = {2757877}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/mrm.1910210215}, citeulike-linkout-1 = {http://www.scopus.com/record/display.url?view=extended&origin=resultslist&eid=2-s2.0-0026005502}, doi = {10.1002/mrm.1910210215}, journal = {Magnetic Resonance in Medicine}, keywords = {13c, brain, glycolysis, lactate, stroke, turnover}, number = {2}, pages = {302--307}, posted-at = {2008-05-05 14:22:33}, priority = {2}, title = {Localized proton NMR observation of [3-13C]lactate in stroke after [1-13C]glucose infusion}, url = {http://dx.doi.org/10.1002/mrm.1910210215}, volume = {21}, year = {1991} }

TY - JOUR ID - citeulike:2757877 L3 - citeulike-article-id:2757877 N2 - To assess whether elevated lactate in stable stroke is being actively produced from blood glucose localized 1H NMR stimulated echo spectra were obtained from a patient in the region of a 32-day-old cortical infarct before and 60-100 min after infusion of [1-13C]glucose. Prior to the infusion the spectrum from the region of the infarct contained an elevated resonance from C3 lactate and a greatly reduced resonance from N-acetyl groups relative to an unaffected contralateral region. After the infusion two additional resonances were observed at 62 and -64 Hz relative to the unlabeled resonance of C3 lactate which were assigned on the basis of chemical shift and relative intensity to [3-13C]lactate. The [3-13C]lactate fractional enrichment in the infarct region was measured to be 32% which is within error one-half the average [1-13C]plasma glucose enrichment during the postinfusion NMR measurement. The result suggests that the stroke lactate pool was completely derived from infused glucose. IS - 2 JF - Magnetic Resonance in Medicine EP - 307 TI - Localized proton NMR observation of [3-13C]lactate in stroke after [1-13C]glucose infusion VL - 21 SP - 302 KW - 13c KW - brain KW - glycolysis KW - lactate KW - stroke KW - turnover AU - Rothman, DL AU - Howseman, AM AU - Graham, GD AU - Petroff, OAC AU - Lantos, G AU - Fayad, PB AU - Brass, LM AU - Shulman, GI AU - Shulman, RG AU - Prichard, JW PY - 1991/// UR - http://dx.doi.org/10.1002/mrm.1910210215 ER -