Molecular imaging with endogenous substances. Export

@article{citeulike:689748, abstract = {Dynamic nuclear polarization has enabled hyperpolarization of nuclei such as 13C and 15N in endogenous substances. The resulting high nuclear polarization makes it possible to perform subsecond 13C MRI. By using the dynamic nuclear polarization hyperpolarization technique, 10\% polarization was obtained in an aqueous solution of 100 mM 13C-labeled urea, ready for injection. The in vivo T1 relaxation time of 13C in the urea solution was determined to 20 +/- 2 s. Due to the long relaxation time, it is possible to use the hyperpolarized substance for medical imaging. A series of high-resolution ( approximately 1-mm) magnetic resonance images were acquired, each with a scan time of 240 ms, 0-5 s after an i.v. injection of the hyperpolarized aqueous [13C]urea solution in a rat. The results show that it is possible to perform 13C angiography with a signal-to-noise ratio of approximately 275 in approximately 0.25 s. Perfusion studies with endogenous substances may allow higher spatial and/or temporal resolution than is possible with current proton imaging techniques.}, address = {Amersham Health Research and Development AB, Medeon, SE-205 12 Malm\"{o}, Sweden. klaes.golman@amersham.com}, author = {Golman, K. and Ardenkjaer-Larsen, J. H. and Petersson, J. S. and Mansson, S. and Leunbach, I.}, citeulike-article-id = {689748}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.1733836100}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12930896}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12930896}, day = {2}, doi = {10.1073/pnas.1733836100}, issn = {0027-8424}, journal = {Proc Natl Acad Sci U S A}, keywords = {hy}, month = {September}, number = {18}, pages = {10435--10439}, posted-at = {2006-06-08 13:39:14}, priority = {2}, title = {Molecular imaging with endogenous substances.}, url = {http://dx.doi.org/10.1073/pnas.1733836100}, volume = {100}, year = {2003} }

TY - JOUR ID - citeulike:689748 L3 - citeulike-article-id:689748 N2 - Dynamic nuclear polarization has enabled hyperpolarization of nuclei such as 13C and 15N in endogenous substances. The resulting high nuclear polarization makes it possible to perform subsecond 13C MRI. By using the dynamic nuclear polarization hyperpolarization technique, 10% polarization was obtained in an aqueous solution of 100 mM 13C-labeled urea, ready for injection. The in vivo T1 relaxation time of 13C in the urea solution was determined to 20 +/- 2 s. Due to the long relaxation time, it is possible to use the hyperpolarized substance for medical imaging. A series of high-resolution ( approximately 1-mm) magnetic resonance images were acquired, each with a scan time of 240 ms, 0-5 s after an i.v. injection of the hyperpolarized aqueous [13C]urea solution in a rat. The results show that it is possible to perform 13C angiography with a signal-to-noise ratio of approximately 275 in approximately 0.25 s. Perfusion studies with endogenous substances may allow higher spatial and/or temporal resolution than is possible with current proton imaging techniques. IS - 18 JF - Proc Natl Acad Sci U S A SN - 0027-8424 AD - Amersham Health Research and Development AB, Medeon, SE-205 12 Malmö, Sweden. klaes.golman@amersham.com EP - 10439 TI - Molecular imaging with endogenous substances. VL - 100 SP - 10435 KW - hy AU - Golman, K AU - Ardenkjaer-Larsen, JH AU - Petersson, JS AU - Mansson, S AU - Leunbach, I PY - 2003/09/02/ UR - http://dx.doi.org/10.1073/pnas.1733836100 ER -