Genetic instability and darwinian selection in tumours. Export

@article{citeulike:710794, abstract = {Genetic instability has long been hypothesized to be a cardinal feature of cancer. Recent work has strengthened the proposal that mutational alterations conferring instability occur early during tumour formation. The ensuing genetic instability drives tumour progression by generating mutations in oncogenes and tumour-suppressor genes. These mutant genes provide cancer cells with a selective growth advantage, thereby leading to the clonal outgrowth of a tumour. Here, we discuss the role of genetic instability in tumour formation and outline future work necessary to substantiate the genetic instability hypothesis.}, address = {Program in Human Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.}, author = {Cahill, D. P. and Kinzler, K. W. and Vogelstein, B. and Lengauer, C.}, citeulike-article-id = {710794}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10611684}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10611684}, issn = {0962-8924}, journal = {Trends Cell Biol}, keywords = {cancer, genetic, mutator-phenotype}, month = {December}, number = {12}, posted-at = {2006-06-26 09:10:57}, priority = {2}, title = {Genetic instability and darwinian selection in tumours.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10611684}, volume = {9}, year = {1999} }

TY - JOUR ID - citeulike:710794 L3 - citeulike-article-id:710794 N2 - Genetic instability has long been hypothesized to be a cardinal feature of cancer. Recent work has strengthened the proposal that mutational alterations conferring instability occur early during tumour formation. The ensuing genetic instability drives tumour progression by generating mutations in oncogenes and tumour-suppressor genes. These mutant genes provide cancer cells with a selective growth advantage, thereby leading to the clonal outgrowth of a tumour. Here, we discuss the role of genetic instability in tumour formation and outline future work necessary to substantiate the genetic instability hypothesis. IS - 12 JF - Trends Cell Biol SN - 0962-8924 AD - Program in Human Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. TI - Genetic instability and darwinian selection in tumours. VL - 9 KW - cancer KW - genetic KW - mutator-phenotype AU - Cahill, DP AU - Kinzler, KW AU - Vogelstein, B AU - Lengauer, C PY - 1999/12// UR - http://view.ncbi.nlm.nih.gov/pubmed/10611684 ER -