Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members Export

@article{citeulike:710886, abstract = {SummaryWe show that the antiapoptotic proteins BCL-2, BCL-XL, MCL-1, BFL-1, and BCL-w each bear a unique pattern of interaction with a panel of peptides derived from BH3 domains of BH3-only proteins. Cellular dependence on an antiapoptotic protein for survival can be decoded based on the pattern of mitochondrial sensitivity to this peptide panel, a strategy that we call BH3 profiling. Dependence on antiapoptotic proteins correlates with sequestration of activator BH3-only proteins like BID or BIM by antiapoptotic proteins. Sensitivity to the cell-permeable BCL-2 antagonist ABT-737 is also related to priming of BCL-2 by activator BH3-only molecules. Our data allow us to distinguish a cellular state we call "primed for death," which can be determined by BH3 profiling and which correlates with dependence on antiapoptotic family members for survival.}, author = {Certo, Michael and Moore, Victoria D. and Nishino, Mari and Wei, Guo and Korsmeyer, Stanley and Armstrong, Scott A. and Letai, Anthony}, citeulike-article-id = {710886}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.ccr.2006.03.027}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6WWK-4JYKG3R-6/2/7cfb18eb553dfcf062288b5f63d00f77}, doi = {10.1016/j.ccr.2006.03.027}, journal = {Cancer Cell}, keywords = {apoptosis, apoptotic-balance, bcl2, mitochondria}, month = {May}, number = {5}, pages = {351--365}, posted-at = {2006-06-26 11:10:05}, priority = {2}, title = {Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members}, url = {http://dx.doi.org/10.1016/j.ccr.2006.03.027}, volume = {9}, year = {2006} }

TY - JOUR ID - citeulike:710886 L3 - citeulike-article-id:710886 N2 - SummaryWe show that the antiapoptotic proteins BCL-2, BCL-XL, MCL-1, BFL-1, and BCL-w each bear a unique pattern of interaction with a panel of peptides derived from BH3 domains of BH3-only proteins. Cellular dependence on an antiapoptotic protein for survival can be decoded based on the pattern of mitochondrial sensitivity to this peptide panel, a strategy that we call BH3 profiling. Dependence on antiapoptotic proteins correlates with sequestration of activator BH3-only proteins like BID or BIM by antiapoptotic proteins. Sensitivity to the cell-permeable BCL-2 antagonist ABT-737 is also related to priming of BCL-2 by activator BH3-only molecules. Our data allow us to distinguish a cellular state we call "primed for death," which can be determined by BH3 profiling and which correlates with dependence on antiapoptotic family members for survival. IS - 5 JF - Cancer Cell EP - 365 TI - Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members VL - 9 SP - 351 KW - apoptosis KW - apoptotic-balance KW - bcl2 KW - mitochondria AU - Certo, Michael AU - Moore, Victoria AU - Nishino, Mari AU - Wei, Guo AU - Korsmeyer, Stanley AU - Armstrong, Scott AU - Letai, Anthony PY - 2006/05// UR - http://dx.doi.org/10.1016/j.ccr.2006.03.027 ER -