Glucose decreases respiratory control ratio in EL-4 tumor cells. Export

@article{citeulike:710968, abstract = {EL-4 ascites thymoma cells are shown to have high aerobic glycolysis and decreased Pasteur effect. At the same time, glucose produces a much smaller inhibitory effect on cell respiration (Crabtree effect) than in Ehrlich ascites carcinoma (EAC) cells. In intact EL-4 cells, the respiratory control ratio (RCR) was found to be 6.2 with endogenous substrates and 8.0 with glutamine. Glucose decreased the RCR to 3.2, by stimulating the state 4 respiration. In rat thymocytes and EAC cells, such an effect of glucose was absent (RCR of 7.0 and 7.2, respectively). It is suggested that in EL-4 tumor cells, the high aerobic glycolysis and small Crabtree effect may be due to glucose-induced 'uncoupling' of oxidation and phosphorylation.}, address = {Institute of Medical Radiology, Russian Academy of Medical Sciences, Obninsk.}, author = {Gabai, V. L.}, citeulike-article-id = {710968}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/1426278}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=1426278}, day = {23}, issn = {0014-5793}, journal = {FEBS Lett}, keywords = {el4, oxygen-consumption}, month = {November}, number = {2}, pages = {126--128}, posted-at = {2006-06-26 13:21:00}, priority = {2}, title = {Glucose decreases respiratory control ratio in EL-4 tumor cells.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/1426278}, volume = {313}, year = {1992} }

TY - JOUR ID - citeulike:710968 L3 - citeulike-article-id:710968 N2 - EL-4 ascites thymoma cells are shown to have high aerobic glycolysis and decreased Pasteur effect. At the same time, glucose produces a much smaller inhibitory effect on cell respiration (Crabtree effect) than in Ehrlich ascites carcinoma (EAC) cells. In intact EL-4 cells, the respiratory control ratio (RCR) was found to be 6.2 with endogenous substrates and 8.0 with glutamine. Glucose decreased the RCR to 3.2, by stimulating the state 4 respiration. In rat thymocytes and EAC cells, such an effect of glucose was absent (RCR of 7.0 and 7.2, respectively). It is suggested that in EL-4 tumor cells, the high aerobic glycolysis and small Crabtree effect may be due to glucose-induced 'uncoupling' of oxidation and phosphorylation. IS - 2 JF - FEBS Lett SN - 0014-5793 AD - Institute of Medical Radiology, Russian Academy of Medical Sciences, Obninsk. EP - 128 TI - Glucose decreases respiratory control ratio in EL-4 tumor cells. VL - 313 SP - 126 KW - el4 KW - oxygen-consumption AU - Gabai, VL PY - 1992/11/23/ UR - http://view.ncbi.nlm.nih.gov/pubmed/1426278 ER -