Mitochondrial regulation of apoptotic cell death Export

@article{citeulike:711304, abstract = {Mitochondria play a decisive role in the regulation of both apoptotic and necrotic cell death. Permeabilization of the outer mitochondrial membrane and subsequent release of intermembrane space proteins are important features of both models of cell death. The mechanisms by which these proteins are released depend presumably on cell type and the nature of stimuli. Of the mechanisms involved, mitochondrial permeability transition appears to be associated mainly with necrosis, whereas the release of caspase activating proteins during early apoptosis is regulated primarily by the Bcl-2 family of proteins. However, there is increasing evidence for interaction and co-operation between these two mechanisms. The multiple mechanisms of mitochondrial permeabilization may explain diversities in the response of mitochondria to numerous apoptotic stimuli in different types of cells.}, author = {Gogvadze, Vladimir and Orrenius, Sten}, citeulike-article-id = {711304}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cbi.2006.04.010}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0009279706000913}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16730343}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16730343}, citeulike-linkout-4 = {http://www.sciencedirect.com/science/article/B6T56-4JVBVD1-1/2/01faeda41fd615db843c632918911ed8}, doi = {10.1016/j.cbi.2006.04.010}, journal = {Chemico-Biological Interactions}, keywords = {apoptosis, apoptotic-balance, bcl2, mitochondria}, posted-at = {2006-06-26 13:43:01}, priority = {2}, title = {Mitochondrial regulation of apoptotic cell death}, url = {http://dx.doi.org/10.1016/j.cbi.2006.04.010}, volume = {In Press, Corrected Proof} }

TY - JOUR ID - citeulike:711304 L3 - citeulike-article-id:711304 N2 - Mitochondria play a decisive role in the regulation of both apoptotic and necrotic cell death. Permeabilization of the outer mitochondrial membrane and subsequent release of intermembrane space proteins are important features of both models of cell death. The mechanisms by which these proteins are released depend presumably on cell type and the nature of stimuli. Of the mechanisms involved, mitochondrial permeability transition appears to be associated mainly with necrosis, whereas the release of caspase activating proteins during early apoptosis is regulated primarily by the Bcl-2 family of proteins. However, there is increasing evidence for interaction and co-operation between these two mechanisms. The multiple mechanisms of mitochondrial permeabilization may explain diversities in the response of mitochondria to numerous apoptotic stimuli in different types of cells. JF - Chemico-Biological Interactions TI - Mitochondrial regulation of apoptotic cell death VL - In Press, Corrected Proof KW - apoptosis KW - apoptotic-balance KW - bcl2 KW - mitochondria AU - Gogvadze, Vladimir AU - Orrenius, Sten UR - http://dx.doi.org/10.1016/j.cbi.2006.04.010 ER -