Cellular pH regulators: potentially promising molecular targets for cancer chemotherapy Export

@article{citeulike:782527, abstract = {One of the major obstacles to the successful treatment of cancer is the complex biology of solid tumour development. Although regulation of intracellular pH has been shown to be critically important for many cellular functions, pH regulation has not been fully investigated in the field of cancer. It has, however, been shown that cellular pH is crucial for biological functions such as cell proliferation, invasion and metastasis, drug resistance and apoptosis. Hypoxic conditions are often observed during the development of solid tumours and lead to intracellular and extracellular acidosis. Cellular acidosis has been shown to be a trigger in the early phase of apoptosis and leads to activation of endonucleases inducing DNA fragmentation. To avoid intracellular acidification under such conditions, pH regulators are thought to be up-regulated in tumour cells. Four major types of pH regulator have been identified: the proton pump, the sodium-proton exchanger family (NHE), the bicarbonate transporter family (BCT) and the monocarboxylate transporter family (MCT). Here, we describe the structure and function of pH regulators expressed in tumour tissue. Understanding pH regulation in tumour cells may provide new ways of inducing tumour-specific apoptosis, thus aiding cancer chemotherapy.}, author = {Izumi, Hiroto and Torigoe, Takayuki and Ishiguchi, Hiroshi and Uramoto, Hidetaka and Yoshida, Yoichiro and Tanabe, Mizuho and Ise, Tomoko and Murakami, Tadashi and Yoshida, Takeshi and Nomoto, Minoru and Kohno, Kimitoshi}, citeulike-article-id = {782527}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0305-7372(03)00106-3}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6WC8-48S317P-3/2/5d0dafd513b7c8ac1e8ffd18dbbfbf60}, doi = {10.1016/S0305-7372(03)00106-3}, journal = {Cancer Treatment Reviews}, keywords = {cancer, chemotherapy, lactate, mct, ph}, month = {December}, number = {6}, pages = {541--549}, posted-at = {2006-08-02 08:50:57}, priority = {2}, title = {Cellular pH regulators: potentially promising molecular targets for cancer chemotherapy}, url = {http://dx.doi.org/10.1016/S0305-7372(03)00106-3}, volume = {29}, year = {2003} }

TY - JOUR ID - citeulike:782527 L3 - citeulike-article-id:782527 N2 - One of the major obstacles to the successful treatment of cancer is the complex biology of solid tumour development. Although regulation of intracellular pH has been shown to be critically important for many cellular functions, pH regulation has not been fully investigated in the field of cancer. It has, however, been shown that cellular pH is crucial for biological functions such as cell proliferation, invasion and metastasis, drug resistance and apoptosis. Hypoxic conditions are often observed during the development of solid tumours and lead to intracellular and extracellular acidosis. Cellular acidosis has been shown to be a trigger in the early phase of apoptosis and leads to activation of endonucleases inducing DNA fragmentation. To avoid intracellular acidification under such conditions, pH regulators are thought to be up-regulated in tumour cells. Four major types of pH regulator have been identified: the proton pump, the sodium-proton exchanger family (NHE), the bicarbonate transporter family (BCT) and the monocarboxylate transporter family (MCT). Here, we describe the structure and function of pH regulators expressed in tumour tissue. Understanding pH regulation in tumour cells may provide new ways of inducing tumour-specific apoptosis, thus aiding cancer chemotherapy. IS - 6 JF - Cancer Treatment Reviews EP - 549 TI - Cellular pH regulators: potentially promising molecular targets for cancer chemotherapy VL - 29 SP - 541 KW - cancer KW - chemotherapy KW - lactate KW - mct KW - ph AU - Izumi, Hiroto AU - Torigoe, Takayuki AU - Ishiguchi, Hiroshi AU - Uramoto, Hidetaka AU - Yoshida, Yoichiro AU - Tanabe, Mizuho AU - Ise, Tomoko AU - Murakami, Tadashi AU - Yoshida, Takeshi AU - Nomoto, Minoru AU - Kohno, Kimitoshi PY - 2003/12// UR - http://dx.doi.org/10.1016/S0305-7372(03)00106-3 ER -