An importin alpha homolog, MOS6, plays an important role in plant innate immunity. Export

@article{citeulike:1100061, abstract = {Plant disease resistance is the consequence of an innate defense mechanism mediated by Resistance (R) genes [1]. The conserved structure of one class of R protein is reminiscent of Toll-like receptors (TLRs) and Nucleotide binding oligomerization domain (NOD) proteins-immune-response perception modules in animal cells [2, 3, and 4]. The Arabidopsis snc1 (suppressor of npr1-1, constitutive, 1) mutant contains a mutation in a TIR-NBS-LRR-type of R gene that renders resistance responses constitutively active without interaction with pathogens [5]. Few components of the downstream signaling network activated by snc1 are known. To search for regulators of R-gene-mediated resistance, we screened for genetic suppressors of snc1. Three alleles of the mutant mos6 (modifier of snc1, 6) partially suppressed constitutive-resistance responses and immunity to virulent pathogens in snc1. Furthermore, the mos6-1 single mutant exhibited enhanced disease susceptibility to a virulent oomycete pathogen. MOS6, identified by positional cloning, encodes importin alpha3, one of eight alpha importins in Arabidopsis [6]. alpha importins mediate the import of specific proteins across the nuclear envelope. We previously reported that MOS3, a protein homologous to human nucleoporin 96, is required for constitutive resistance in snc1 [7]. Our data highlight an essential role for nucleo-cytoplasmic trafficking, especially protein import, in plant innate immunity.}, address = {Michael Smith Laboratories, Room 301, 2185 East Mall, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.}, author = {Palma, K. and Zhang, Y. and Li, X.}, citeulike-article-id = {1100061}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cub.2005.05.022}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15964279}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15964279}, day = {21}, doi = {10.1016/j.cub.2005.05.022}, issn = {0960-9822}, journal = {Curr Biol}, keywords = {importin, mos}, month = {June}, number = {12}, pages = {1129--1135}, posted-at = {2007-02-11 07:18:37}, priority = {0}, title = {An importin alpha homolog, MOS6, plays an important role in plant innate immunity.}, url = {http://dx.doi.org/10.1016/j.cub.2005.05.022}, volume = {15}, year = {2005} }

TY - JOUR ID - citeulike:1100061 L3 - citeulike-article-id:1100061 N2 - Plant disease resistance is the consequence of an innate defense mechanism mediated by Resistance (R) genes [1]. The conserved structure of one class of R protein is reminiscent of Toll-like receptors (TLRs) and Nucleotide binding oligomerization domain (NOD) proteins-immune-response perception modules in animal cells [2, 3, and 4]. The Arabidopsis snc1 (suppressor of npr1-1, constitutive, 1) mutant contains a mutation in a TIR-NBS-LRR-type of R gene that renders resistance responses constitutively active without interaction with pathogens [5]. Few components of the downstream signaling network activated by snc1 are known. To search for regulators of R-gene-mediated resistance, we screened for genetic suppressors of snc1. Three alleles of the mutant mos6 (modifier of snc1, 6) partially suppressed constitutive-resistance responses and immunity to virulent pathogens in snc1. Furthermore, the mos6-1 single mutant exhibited enhanced disease susceptibility to a virulent oomycete pathogen. MOS6, identified by positional cloning, encodes importin alpha3, one of eight alpha importins in Arabidopsis [6]. alpha importins mediate the import of specific proteins across the nuclear envelope. We previously reported that MOS3, a protein homologous to human nucleoporin 96, is required for constitutive resistance in snc1 [7]. Our data highlight an essential role for nucleo-cytoplasmic trafficking, especially protein import, in plant innate immunity. IS - 12 JF - Curr Biol SN - 0960-9822 AD - Michael Smith Laboratories, Room 301, 2185 East Mall, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada. EP - 1135 TI - An importin alpha homolog, MOS6, plays an important role in plant innate immunity. VL - 15 SP - 1129 KW - importin KW - mos AU - Palma, K AU - Zhang, Y AU - Li, X PY - 2005/06/21/ UR - http://dx.doi.org/10.1016/j.cub.2005.05.022 ER -