Antagonistic control of disease resistance protein stability in the plant immune system. Export

@article{citeulike:1389527, abstract = {Pathogen recognition by the plant immune system is governed by structurally related, polymorphic products of disease resistance (R) genes. RAR1 and/or SGT1b mediate the function of many R proteins. RAR1 controls preactivation R protein accumulation by an unknown mechanism. We demonstrate that Arabidopsis SGT1b has two distinct, genetically separable functions in the plant immune system: SGT1b antagonizes RAR1 to negatively regulate R protein accumulation before infection, and SGT1b has a RAR1-independent function that regulates programmed cell death during infection. The balanced activities of RAR1 and SGT1, in concert with cytosolic HSP90, modulate preactivation R protein accumulation and signaling competence.}, address = {Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.}, author = {Holt, B. F. and Belkhadir, Y. and Dangl, J. L.}, citeulike-article-id = {1389527}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1109977}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15976272}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15976272}, day = {5}, doi = {10.1126/science.1109977}, issn = {1095-9203}, journal = {Science}, keywords = {hsp90, r, rar, sgt}, month = {August}, number = {5736}, pages = {929--932}, posted-at = {2007-06-14 09:08:30}, priority = {2}, title = {Antagonistic control of disease resistance protein stability in the plant immune system.}, url = {http://dx.doi.org/10.1126/science.1109977}, volume = {309}, year = {2005} }

TY - JOUR ID - citeulike:1389527 L3 - citeulike-article-id:1389527 N2 - Pathogen recognition by the plant immune system is governed by structurally related, polymorphic products of disease resistance (R) genes. RAR1 and/or SGT1b mediate the function of many R proteins. RAR1 controls preactivation R protein accumulation by an unknown mechanism. We demonstrate that Arabidopsis SGT1b has two distinct, genetically separable functions in the plant immune system: SGT1b antagonizes RAR1 to negatively regulate R protein accumulation before infection, and SGT1b has a RAR1-independent function that regulates programmed cell death during infection. The balanced activities of RAR1 and SGT1, in concert with cytosolic HSP90, modulate preactivation R protein accumulation and signaling competence. IS - 5736 JF - Science SN - 1095-9203 AD - Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA. EP - 932 TI - Antagonistic control of disease resistance protein stability in the plant immune system. VL - 309 SP - 929 KW - hsp90 KW - r KW - rar KW - sgt AU - Holt, BF AU - Belkhadir, Y AU - Dangl, JL PY - 2005/08/05/ UR - http://dx.doi.org/10.1126/science.1109977 ER -