Regulation of plant innate immunity by three proteins in a complex conserved across the plant and animal kingdoms Export

@article{citeulike:1401872, abstract = {Innate immunity against pathogen infection is an evolutionarily conserved process among multicellular organisms. Arabidopsis SNC1 encodes a Resistance protein that combines attributes of multiple mammalian pattern recognition receptors. Utilizing snc1 as an autoimmune model, we identified a discrete protein complex containing at least three members--MOS4 (Modifier Of snc1, 4), AtCDC5, and PRL1 (Pleiotropic Regulatory Locus 1)--that are all essential for plant innate immunity. AtCDC5 has DNA-binding activity, suggesting that this complex probably regulates defense responses through transcriptional control. Since the complex components along with their interactions are highly conserved from fission yeast to Arabidopsis and human, they may also have a yet-to-be-identified function in mammalian innate immunity. 10.1101/gad.1559607}, author = {Palma, Kristoffer and Zhao, Qingguo and Cheng, Yu T. and Bi, Dongling and Monaghan, Jacqueline and Cheng, Wei and Zhang, Yuelin and Li, Xin}, citeulike-article-id = {1401872}, citeulike-linkout-0 = {http://dx.doi.org/10.1101/gad.1559607}, citeulike-linkout-1 = {http://www.genesdev.org/cgi/content/abstract/21/12/1484}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17575050}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17575050}, doi = {10.1101/gad.1559607}, journal = {Genes Dev.}, keywords = {cdc, mos, npr1, snc1}, month = {June}, number = {12}, pages = {1484--1493}, posted-at = {2007-06-21 05:33:25}, priority = {2}, title = {Regulation of plant innate immunity by three proteins in a complex conserved across the plant and animal kingdoms}, url = {http://dx.doi.org/10.1101/gad.1559607}, volume = {21}, year = {2007} }

TY - JOUR ID - citeulike:1401872 L3 - citeulike-article-id:1401872 N2 - Innate immunity against pathogen infection is an evolutionarily conserved process among multicellular organisms. Arabidopsis SNC1 encodes a Resistance protein that combines attributes of multiple mammalian pattern recognition receptors. Utilizing snc1 as an autoimmune model, we identified a discrete protein complex containing at least three members--MOS4 (Modifier Of snc1, 4), AtCDC5, and PRL1 (Pleiotropic Regulatory Locus 1)--that are all essential for plant innate immunity. AtCDC5 has DNA-binding activity, suggesting that this complex probably regulates defense responses through transcriptional control. Since the complex components along with their interactions are highly conserved from fission yeast to Arabidopsis and human, they may also have a yet-to-be-identified function in mammalian innate immunity. 10.1101/gad.1559607 IS - 12 JF - Genes Dev. EP - 1493 TI - Regulation of plant innate immunity by three proteins in a complex conserved across the plant and animal kingdoms VL - 21 SP - 1484 KW - cdc KW - mos KW - npr1 KW - snc1 AU - Palma, Kristoffer AU - Zhao, Qingguo AU - Cheng, Yu AU - Bi, Dongling AU - Monaghan, Jacqueline AU - Cheng, Wei AU - Zhang, Yuelin AU - Li, Xin PY - 2007/06/15/ UR - http://dx.doi.org/10.1101/gad.1559607 ER -