Paramutation in maize. Export

@article{citeulike:833289, abstract = {Paramutation is a heritable change in gene expression induced by allele interactions. This review summarizes key experiments on three maize loci, which undergo paramutation. Similarities and differences between the phenomenology at the three loci are described. In spite of many differences with respect to the stability of the reduced expression states at each locus or whether paramutation correlates with DNA methylation and repeated sequences within the loci, recent experiments are consistent with a common mechanism underlying paramutation at all three loci. Most strikingly, trans-acting mutants have been isolated that prevent paramutation at all three loci and lead to the activation of silenced Mutator transposable elements. Models consistent with the hypothesis that paramutation involves heritable changes in chromatin structure are presented. Several potential roles for paramutation are discussed. These include localizing recombination to low-copy sequences within the genome, establishing and maintaining chromatin domain boundaries, and providing a mechanism for plants to transmit an environmentally influenced expression state to progeny.}, address = {Department of Plant Sciences, University of Arizona, Tucson 85721, USA. chandler@ag.arizona.edu}, author = {Chandler, V. L. and Eggleston, W. B. and Dorweiler, J. E.}, citeulike-article-id = {833289}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10999400}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10999400}, issn = {0167-4412}, journal = {Plant Mol Biol}, keywords = {epigenetics}, month = {June}, number = {2-3}, pages = {121--145}, posted-at = {2006-09-07 04:38:32}, priority = {2}, title = {Paramutation in maize.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10999400}, volume = {43}, year = {2000} }

TY - JOUR ID - citeulike:833289 L3 - citeulike-article-id:833289 N2 - Paramutation is a heritable change in gene expression induced by allele interactions. This review summarizes key experiments on three maize loci, which undergo paramutation. Similarities and differences between the phenomenology at the three loci are described. In spite of many differences with respect to the stability of the reduced expression states at each locus or whether paramutation correlates with DNA methylation and repeated sequences within the loci, recent experiments are consistent with a common mechanism underlying paramutation at all three loci. Most strikingly, trans-acting mutants have been isolated that prevent paramutation at all three loci and lead to the activation of silenced Mutator transposable elements. Models consistent with the hypothesis that paramutation involves heritable changes in chromatin structure are presented. Several potential roles for paramutation are discussed. These include localizing recombination to low-copy sequences within the genome, establishing and maintaining chromatin domain boundaries, and providing a mechanism for plants to transmit an environmentally influenced expression state to progeny. IS - 2-3 JF - Plant Mol Biol SN - 0167-4412 AD - Department of Plant Sciences, University of Arizona, Tucson 85721, USA. chandler@ag.arizona.edu EP - 145 TI - Paramutation in maize. VL - 43 SP - 121 KW - epigenetics AU - Chandler, VL AU - Eggleston, WB AU - Dorweiler, JE PY - 2000/06// UR - http://view.ncbi.nlm.nih.gov/pubmed/10999400 ER -