Hydrophobicity at Small and Large Length Scales

by: K Lum, D Chandler, JD Weeks

J. Phys. Chem. B, Vol. 103, No. 22. (3 June 1999), pp. 4570-4577.

View FullText article

DOI, American Chem. Soc. Publications

Reviews [Write a review of this article]

There are no reviews of this article

Find related articles from these CiteULike users

Find related articles with these CiteULike tags

hydrophobicity

Abstract

Abstract: We develop a unified and generally applicable theory of solvation of small and large apolar species in water. In the former, hydrogen bonding of water is hindered yet persists near the solutes. In the latter, hydrogen bonding is depleted, leading to drying of extended apolar surfaces, large forces of attraction, and hysteresis on mesoscopic length scales. The crossover occurs on nanometer length scales, when the local concentration of apolar units is sufficiently high, or when an apolar surface is sufficiently large. Our theory for the crossover has implications concerning the stability of protein assemblies and protein folding.

@article{lum99, abstract = {Abstract: We develop a unified and generally applicable theory of solvation of small and large apolar species in water. In the former, hydrogen bonding of water is hindered yet persists near the solutes. In the latter, hydrogen bonding is depleted, leading to drying of extended apolar surfaces, large forces of attraction, and hysteresis on mesoscopic length scales. The crossover occurs on nanometer length scales, when the local concentration of apolar units is sufficiently high, or when an apolar surface is sufficiently large. Our theory for the crossover has implications concerning the stability of protein assemblies and protein folding.}, address = {Department of Chemistry, University of California, Berkeley, California 94720, and Institute for Physical Science and Technology and Department of Chemistry, University of Maryland, College Park, Maryland 20742}, author = {Lum, K. and Chandler, D. and Weeks, J. D. }, citeulike-article-id = {2073746}, doi = {10.1021/jp984327m}, journal = {J. Phys. Chem. B}, keywords = {hydrophobicity}, month = {June}, number = {22}, pages = {4570--4577}, posted-at = {2007-12-07 15:58:55}, priority = {2}, title = {Hydrophobicity at Small and Large Length Scales}, url = {http://dx.doi.org/10.1021/jp984327m}, volume = {103}, year = {1999} }

RIS record

TY - JOUR ID - lum99 L3 - citeulike-article-id:2073746 TI - Hydrophobicity at Small and Large Length Scales JF - J. Phys. Chem. B VL - 103 IS - 22 SP - 4570 EP - 4577 AD - Department of Chemistry, University of California, Berkeley, California 94720, and Institute for Physical Science and Technology and Department of Chemistry, University of Maryland, College Park, Maryland 20742 N2 - Abstract: We develop a unified and generally applicable theory of solvation of small and large apolar species in water. In the former, hydrogen bonding of water is hindered yet persists near the solutes. In the latter, hydrogen bonding is depleted, leading to drying of extended apolar surfaces, large forces of attraction, and hysteresis on mesoscopic length scales. The crossover occurs on nanometer length scales, when the local concentration of apolar units is sufficiently high, or when an apolar surface is sufficiently large. Our theory for the crossover has implications concerning the stability of protein assemblies and protein folding. KW - hydrophobicity AU - Lum, K AU - Chandler, D AU - Weeks, JD PY - 1999/06/03/ UR - http://dx.doi.org/10.1021/jp984327m ER -

RIS BibTeX