Statistical mechanics of supercoiled DNA Export

@article{marko94, abstract = {The two strands of a closed circular DNA molecule possess as a topological invariant their linking number. This property; combined with an appreciable twist elastic constant; causes the double helix to assume a supercoiled conformation in space when a nonequilibrium twist is imposed. Thermal fluctuations play a crucial role in determining the conformation of supercoils; setting the linking number scale at which a well defined interwound supercoil forms. In addition to equilibrium supercoil structure; we discuss supercoil bending and branching and show how at large scales supercoiled DNA becomes a branched polymer. The characteristic time required for intrasupercoil reactions to occur and the force necessary to extend twisted DNA are also derived.}, author = {Marko, J. F. and Siggia, E. D.}, citeulike-article-id = {5822653}, citeulike-linkout-0 = {http://dx.doi.org/10.1103/PhysRevE.52.2912}, citeulike-linkout-1 = {http://link.aps.org/abstract/PRE/v52/i3/p2912_1}, citeulike-linkout-2 = {http://link.aps.org/pdf/PRE/v52/i3/p2912_1}, doi = {10.1103/PhysRevE.52.2912}, journal = {Physical Review E}, keywords = {bending, dna, marko-siggia}, month = {Sep}, number = {3}, pages = {2912--2938}, posted-at = {2009-09-22 19:57:57}, priority = {2}, publisher = {American Physical Society}, title = {Statistical mechanics of supercoiled DNA}, url = {http://dx.doi.org/10.1103/PhysRevE.52.2912}, volume = {52}, year = {1995} }

TY - JOUR ID - marko94 L3 - citeulike-article-id:5822653 N2 - The two strands of a closed circular DNA molecule possess as a topological invariant their linking number. This property; combined with an appreciable twist elastic constant; causes the double helix to assume a supercoiled conformation in space when a nonequilibrium twist is imposed. Thermal fluctuations play a crucial role in determining the conformation of supercoils; setting the linking number scale at which a well defined interwound supercoil forms. In addition to equilibrium supercoil structure; we discuss supercoil bending and branching and show how at large scales supercoiled DNA becomes a branched polymer. The characteristic time required for intrasupercoil reactions to occur and the force necessary to extend twisted DNA are also derived. IS - 3 JF - Physical Review E EP - 2938 TI - Statistical mechanics of supercoiled DNA PB - American Physical Society VL - 52 SP - 2912 KW - bending KW - dna KW - marko-siggia AU - Marko, JF AU - Siggia, ED PY - 1995/Sep// UR - http://dx.doi.org/10.1103/PhysRevE.52.2912 ER -