Expression pattern and, surprisingly, gene length shape codon usage in Caenorhabditis, Drosophila, and Arabidopsis Export

@article{citeulike:408095, abstract = {We measured the expression pattern and analyzed codon usage in 8,133, 1,550, and 2,917 genes, respectively, from , , and . In those three species, we observed a clear correlation between codon usage and gene expression levels and showed that this correlation is not due to a mutational bias. This provides direct evidence for selection on silent sites in those three distantly related multicellular eukaryotes. Surprisingly, there is a strong negative correlation between codon usage and protein length. This effect is not due to a smaller size of highly expressed proteins. Thus, for a same-expression pattern, the selective pressure on codon usage appears to be lower in genes encoding long rather than short proteins. This puzzling observation is not predicted by any of the current models of selection on codon usage and thus raises the question of how translation efficiency affects fitness in multicellular organisms.}, address = {Laboratoire de Biom\'{e}trie, G\'{e}n\'{e}tique et Biologie des Populations, Unit\'{e} Mixte de Recherche Centre National de la Recherche Scientifique 5558, Villeurbanne Cedex, France. duret@biomserv.univ-lyon1.fr}, author = {Duret, Laurent and Mouchiroud, Dominique}, citeulike-article-id = {408095}, citeulike-linkout-0 = {http://www.pnas.org/content/96/8/4482.abstract}, citeulike-linkout-1 = {http://www.pnas.org/content/96/8/4482.full.pdf}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/10200288}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=10200288}, citeulike-linkout-4 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00003504}, day = {13}, issn = {0027-8424}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {boundaries, codon, exon, usage}, month = {April}, number = {8}, pages = {4482--4487}, posted-at = {2009-10-30 11:59:55}, priority = {2}, title = {Expression pattern and, surprisingly, gene length shape codon usage in Caenorhabditis, Drosophila, and Arabidopsis}, url = {http://www.pnas.org/content/96/8/4482.abstract}, volume = {96}, year = {1999} }

TY - JOUR ID - citeulike:408095 L3 - citeulike-article-id:408095 N2 - We measured the expression pattern and analyzed codon usage in 8,133, 1,550, and 2,917 genes, respectively, from , , and . In those three species, we observed a clear correlation between codon usage and gene expression levels and showed that this correlation is not due to a mutational bias. This provides direct evidence for selection on silent sites in those three distantly related multicellular eukaryotes. Surprisingly, there is a strong negative correlation between codon usage and protein length. This effect is not due to a smaller size of highly expressed proteins. Thus, for a same-expression pattern, the selective pressure on codon usage appears to be lower in genes encoding long rather than short proteins. This puzzling observation is not predicted by any of the current models of selection on codon usage and thus raises the question of how translation efficiency affects fitness in multicellular organisms. IS - 8 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 0027-8424 AD - Laboratoire de Biométrie, Génétique et Biologie des Populations, Unité Mixte de Recherche Centre National de la Recherche Scientifique 5558, Villeurbanne Cedex, France. duret@biomserv.univ-lyon1.fr EP - 4487 TI - Expression pattern and, surprisingly, gene length shape codon usage in Caenorhabditis, Drosophila, and Arabidopsis VL - 96 SP - 4482 KW - boundaries KW - codon KW - exon KW - usage AU - Duret, Laurent AU - Mouchiroud, Dominique PY - 1999/04/13/ UR - http://www.pnas.org/content/96/8/4482.abstract ER -