Structural conservation of a short, functional, peptide-sequence motif. Export

@article{citeulike:6093117, abstract = {Full length, eukaryotic proteins generally consist of several autonomously folding and functioning domains. Many of these domains are known to function by binding and/or modifying other partner proteins based on the recognition of a short, linear amino sequence contained within the target protein. This article reviews the many bioinformatic tools and resources which discover, define and catalogue the various, known protein domains as well as assist users by identifying domain signatures within proteins of interest. We also review the smaller subset of bioinformatic tools which catalogue and help identify the short linear motifs used for domain targeting. It has been suggested that these short, functional, peptide-sequence motifs are normally found in unstructured regions of the target. The role of protein structure in the activity of one representative of these short, functional motifs is explored through an examination of known structures deposited in the Protein Data Bank.}, author = {Fox-Erlich, Susan and Schiller, Martin R. and Gryk, Michael R.}, citeulike-article-id = {6093117}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/19273121}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=19273121}, issn = {1093-4715}, journal = {Frontiers in bioscience : a journal and virtual library}, keywords = {conserved, signalling, structure, unstructured}, pages = {1143--1151}, posted-at = {2009-11-10 13:47:54}, priority = {2}, title = {Structural conservation of a short, functional, peptide-sequence motif.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/19273121}, volume = {14}, year = {2009} }

TY - JOUR ID - citeulike:6093117 L3 - citeulike-article-id:6093117 N2 - Full length, eukaryotic proteins generally consist of several autonomously folding and functioning domains. Many of these domains are known to function by binding and/or modifying other partner proteins based on the recognition of a short, linear amino sequence contained within the target protein. This article reviews the many bioinformatic tools and resources which discover, define and catalogue the various, known protein domains as well as assist users by identifying domain signatures within proteins of interest. We also review the smaller subset of bioinformatic tools which catalogue and help identify the short linear motifs used for domain targeting. It has been suggested that these short, functional, peptide-sequence motifs are normally found in unstructured regions of the target. The role of protein structure in the activity of one representative of these short, functional motifs is explored through an examination of known structures deposited in the Protein Data Bank. JF - Frontiers in bioscience : a journal and virtual library SN - 1093-4715 EP - 1151 TI - Structural conservation of a short, functional, peptide-sequence motif. VL - 14 SP - 1143 KW - conserved KW - signalling KW - structure KW - unstructured AU - Fox-Erlich, Susan AU - Schiller, Martin AU - Gryk, Michael PY - 2009/// UR - http://view.ncbi.nlm.nih.gov/pubmed/19273121 ER -