A Comparison of Three Commercial Perfluorocarbon Emulsions as High-Field 19F NMR Probes of Oxygen Tension and Temperature Export

@article{SH95, abstract = {The increasing use of perfluorocarbons (PFCs) as probes of tissue oxygenation on the basis of the 19 F spin-lattice relaxation rate ( R 1 ) prompts comparison between several commercially available PFC blood-substitute emulsions, The relative sensitivities to both oxygen and temperature of the emulsions Oxypherol, Oxygent, and Fluosol at 7 T have been investigated, The linear response of R 1 with p O 2 was confirmed for each resonance in the range 4-50°C, In general, R 1 is not a linear function of temperature, and we demonstrate this for perfluorotributylamine (FTBA) over an extended range of temperatures, 239-343 K. Theoretical R 1 values of FTBA were compared with experimental data by computer modeling of relaxation mechanisms, To further understand the structure-function relationships of PFCs, 2D COSY experiments were used for the assignment of resonances and as an aid in interpretation of relaxation mechanisms, Finally, the utility of Oxygent and Oxypherol for measuring tissue p O 2 in perfused rat hearts was compared before, during, and after eight minutes of global ischemia.}, author = {Shukla, H.}, citeulike-article-id = {4216938}, citeulike-linkout-0 = {http://dx.doi.org/10.1006/jmrb.1995.1023}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1064-1866(85)71023-0}, doi = {10.1006/jmrb.1995.1023}, issn = {10641866}, journal = {Journal of Magnetic Resonance, Series B}, keywords = {19f-mri, blood, fluosol, oxygent, oxypherol, perfluorocarbons, sh95, substitutes}, month = {February}, number = {2}, pages = {131--141}, posted-at = {2009-03-25 09:31:50}, priority = {0}, title = {A Comparison of Three Commercial Perfluorocarbon Emulsions as High-Field 19F NMR Probes of Oxygen Tension and Temperature}, url = {http://dx.doi.org/10.1006/jmrb.1995.1023}, volume = {106}, year = {1995} }

TY - JOUR ID - SH95 L3 - citeulike-article-id:4216938 N2 - The increasing use of perfluorocarbons (PFCs) as probes of tissue oxygenation on the basis of the 19 F spin-lattice relaxation rate ( R 1 ) prompts comparison between several commercially available PFC blood-substitute emulsions, The relative sensitivities to both oxygen and temperature of the emulsions Oxypherol, Oxygent, and Fluosol at 7 T have been investigated, The linear response of R 1 with p O 2 was confirmed for each resonance in the range 4-50°C, In general, R 1 is not a linear function of temperature, and we demonstrate this for perfluorotributylamine (FTBA) over an extended range of temperatures, 239-343 K. Theoretical R 1 values of FTBA were compared with experimental data by computer modeling of relaxation mechanisms, To further understand the structure-function relationships of PFCs, 2D COSY experiments were used for the assignment of resonances and as an aid in interpretation of relaxation mechanisms, Finally, the utility of Oxygent and Oxypherol for measuring tissue p O 2 in perfused rat hearts was compared before, during, and after eight minutes of global ischemia. IS - 2 JF - Journal of Magnetic Resonance, Series B SN - 10641866 EP - 141 TI - A Comparison of Three Commercial Perfluorocarbon Emulsions as High-Field 19F NMR Probes of Oxygen Tension and Temperature VL - 106 SP - 131 KW - 19f-mri KW - blood KW - fluosol KW - oxygent KW - oxypherol KW - perfluorocarbons KW - sh95 KW - substitutes AU - Shukla, H PY - 1995/02// UR - http://dx.doi.org/10.1006/jmrb.1995.1023 ER -