How does blood oxygen level-dependent (BOLD) contrast correlate with oxygen partial pressure (pO<SUB><FONT SIZE='-1'>2</FONT></SUB>) inside tumors? Export

@article{BA02, abstract = {Blood oxygen level-dependent (BOLD) contrast-based functional MRI (fMRI) has been reported as a method to assess the evolution of tumor oxygenation after hyperoxic treatments, because of its sensitivity to changes in blood flow and deoxyhemoglobin content. However a number of questions remain: 1) In view of tumor heterogeneity, how good is the correlation between the MR parameters in gradient-echo imaging (signal intensity (SI) or effective transverse relaxation time (T*2)) and local tumor oxygen partial pressure (pO2)? 2) Is the magnitude of the change in SI or T*2 a quantitative marker for variation in pO2? 3) Is initial T*2 a good marker for initial pO2? To address these questions, murine tumors were imaged during respiratory challenges at 4.7 Tesla, using fiber-optic microprobes to simultaneously acquire tumor pO2 and erythrocyte flux. The BOLD signal response (SI and T*2) was temporally correlated with changes in pO2. However, the magnitude of the signal bore no absolute relation to pO2 across tumors, i.e., a given change in SI corresponded to a 25 mmHg pO2 change in one tumor, but to a 100 mmHg change in another. The initial T*2 value did not reliably predict tumor oxygenation at the beginning of the experiment. In conclusion, the major advantages of the technique include noninvasiveness, high spatial resolution, and real-time detection of pO2 fluctuations. Information afforded by the BOLD imaging technique is qualitative in nature and may be combined with other techniques capable of providing an absolute measure of pO2. Magn Reson Med 48:980-986, 2002. {\copyright} 2002 Wiley-Liss, Inc.}, address = {Laboratory of Medicinal Chemistry and Radiopharmacy, Universit\'{e} Catholique de Louvain, Brussels, Belgium; Laboratory of Biomedical Magnetic Resonance, Universit\'{e} Catholique de Louvain, Brussels, Belgium}, author = {Baudelet, Christine and Gallez, Bernard}, citeulike-article-id = {4505080}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/mrm.10318}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/101521142/ABSTRACT}, doi = {10.1002/mrm.10318}, journal = {Magnetic Resonance in Medicine}, keywords = {ba02, bold, hypoxia, oximetrie}, number = {6}, pages = {980--986}, posted-at = {2009-05-12 14:12:07}, priority = {0}, title = {How does blood oxygen level-dependent (BOLD) contrast correlate with oxygen partial pressure (pO<SUB><FONT SIZE='-1'>2</FONT></SUB>) inside tumors?}, url = {http://dx.doi.org/10.1002/mrm.10318}, volume = {48}, year = {2002} }

TY - JOUR ID - BA02 L3 - citeulike-article-id:4505080 N2 - Blood oxygen level-dependent (BOLD) contrast-based functional MRI (fMRI) has been reported as a method to assess the evolution of tumor oxygenation after hyperoxic treatments, because of its sensitivity to changes in blood flow and deoxyhemoglobin content. However a number of questions remain: 1) In view of tumor heterogeneity, how good is the correlation between the MR parameters in gradient-echo imaging (signal intensity (SI) or effective transverse relaxation time (T*2)) and local tumor oxygen partial pressure (pO2)? 2) Is the magnitude of the change in SI or T*2 a quantitative marker for variation in pO2? 3) Is initial T*2 a good marker for initial pO2? To address these questions, murine tumors were imaged during respiratory challenges at 4.7 Tesla, using fiber-optic microprobes to simultaneously acquire tumor pO2 and erythrocyte flux. The BOLD signal response (SI and T*2) was temporally correlated with changes in pO2. However, the magnitude of the signal bore no absolute relation to pO2 across tumors, i.e., a given change in SI corresponded to a 25 mmHg pO2 change in one tumor, but to a 100 mmHg change in another. The initial T*2 value did not reliably predict tumor oxygenation at the beginning of the experiment. In conclusion, the major advantages of the technique include noninvasiveness, high spatial resolution, and real-time detection of pO2 fluctuations. Information afforded by the BOLD imaging technique is qualitative in nature and may be combined with other techniques capable of providing an absolute measure of pO2. Magn Reson Med 48:980-986, 2002. © 2002 Wiley-Liss, Inc. IS - 6 JF - Magnetic Resonance in Medicine AD - Laboratory of Medicinal Chemistry and Radiopharmacy, Université Catholique de Louvain, Brussels, Belgium; Laboratory of Biomedical Magnetic Resonance, Université Catholique de Louvain, Brussels, Belgium EP - 986 TI - How does blood oxygen level-dependent (BOLD) contrast correlate with oxygen partial pressure (pO<SUB><FONT SIZE='-1'>2</FONT></SUB>) inside tumors? VL - 48 SP - 980 KW - ba02 KW - bold KW - hypoxia KW - oximetrie AU - Baudelet, Christine AU - Gallez, Bernard PY - 2002/// UR - http://dx.doi.org/10.1002/mrm.10318 ER -