A Neural Representation of Categorization Uncertainty in the Human Brain Export

@article{Grinband:CatUncertaintyBrain, abstract = {SummaryThe ability to classify visual objects into discrete categories ("friend" versus "foe"; "edible" versus "poisonous") is essential for survival and is a fundamental cognitive function. The cortical substrates that mediate this function, however, have not been identified in humans. To identify brain regions involved in stimulus categorization, we developed a task in which subjects classified stimuli according to a variable categorical boundary. Psychophysical functions were used to define a decision variable, categorization uncertainty, which was systematically manipulated. Using event-related functional MRI, we discovered that activity in a fronto-striatal-thalamic network, consisting of the medial frontal gyrus, anterior insula, ventral striatum, and dorsomedial thalamus, was modulated by categorization uncertainty. We found this network to be distinct from the frontoparietal attention network, consisting of the frontal and parietal eye fields, where activity was not correlated with categorization uncertainty.}, author = {Grinband, Jack and Hirsch, Joy and Ferrera, Vincent P.}, citeulike-article-id = {666279}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuron.2006.01.032}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0896627306000894}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16504950}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16504950}, citeulike-linkout-4 = {http://www.sciencedirect.com/science/article/B6WSS-4JCJRN6-J/2/8abf3e542bf73651500b4e05c6d2c835}, day = {2}, doi = {10.1016/j.neuron.2006.01.032}, journal = {Neuron}, keywords = {categorization, fmri, uncertainty}, month = {March}, number = {5}, pages = {757--763}, posted-at = {2006-05-23 16:24:42}, priority = {0}, title = {A Neural Representation of Categorization Uncertainty in the Human Brain}, url = {http://dx.doi.org/10.1016/j.neuron.2006.01.032}, volume = {49}, year = {2006} }

TY - JOUR ID - Grinband:CatUncertaintyBrain L3 - citeulike-article-id:666279 N2 - SummaryThe ability to classify visual objects into discrete categories ("friend" versus "foe"; "edible" versus "poisonous") is essential for survival and is a fundamental cognitive function. The cortical substrates that mediate this function, however, have not been identified in humans. To identify brain regions involved in stimulus categorization, we developed a task in which subjects classified stimuli according to a variable categorical boundary. Psychophysical functions were used to define a decision variable, categorization uncertainty, which was systematically manipulated. Using event-related functional MRI, we discovered that activity in a fronto-striatal-thalamic network, consisting of the medial frontal gyrus, anterior insula, ventral striatum, and dorsomedial thalamus, was modulated by categorization uncertainty. We found this network to be distinct from the frontoparietal attention network, consisting of the frontal and parietal eye fields, where activity was not correlated with categorization uncertainty. IS - 5 JF - Neuron EP - 763 TI - A Neural Representation of Categorization Uncertainty in the Human Brain VL - 49 SP - 757 KW - categorization KW - fmri KW - uncertainty AU - Grinband, Jack AU - Hirsch, Joy AU - Ferrera, Vincent PY - 2006/03/02/ UR - http://dx.doi.org/10.1016/j.neuron.2006.01.032 ER -