Pharmacological Treatment for Heart Failure: A View From the Brain. Export

@article{citeulike:5042892, abstract = {Systolic heart failure is a feed-forward phenomenon with devastating consequences. Impaired cardiac function is the initiating event, but central nervous system mechanisms activated by persistent altered neural and humoral signals from the periphery play an important sustaining role. Animals with experimentally induced heart failure have neurochemical abnormalities in the brain that, when manipulated, profoundly affect sympathetic drive, volume regulation, and cardiac remodeling-critical determinants of outcome. This brief review explores recent studies that provide a strong rationale for the development of pharmaceutical agents that target central nervous system abnormalities in heart failure.Clinical Pharmacology \& Therapeutics (2009); advance online publication 24 June 2009. doi:10.1038/clpt.2009.117.}, author = {Felder, R. B. and Yu, Y. and Zhang, Z-H H. and Wei, S-G G.}, citeulike-article-id = {5042892}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/clpt.2009.117}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19553933}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19553933}, day = {24}, doi = {10.1038/clpt.2009.117}, issn = {1532-6535}, journal = {Clinical pharmacology and therapeutics}, month = {June}, posted-at = {2009-07-02 15:58:20}, priority = {2}, title = {Pharmacological Treatment for Heart Failure: A View From the Brain.}, url = {http://dx.doi.org/10.1038/clpt.2009.117}, year = {2009} }

TY - JOUR ID - citeulike:5042892 L3 - citeulike-article-id:5042892 N2 - Systolic heart failure is a feed-forward phenomenon with devastating consequences. Impaired cardiac function is the initiating event, but central nervous system mechanisms activated by persistent altered neural and humoral signals from the periphery play an important sustaining role. Animals with experimentally induced heart failure have neurochemical abnormalities in the brain that, when manipulated, profoundly affect sympathetic drive, volume regulation, and cardiac remodeling-critical determinants of outcome. This brief review explores recent studies that provide a strong rationale for the development of pharmaceutical agents that target central nervous system abnormalities in heart failure.Clinical Pharmacology & Therapeutics (2009); advance online publication 24 June 2009. doi:10.1038/clpt.2009.117. JF - Clinical pharmacology and therapeutics SN - 1532-6535 TI - Pharmacological Treatment for Heart Failure: A View From the Brain. AU - Felder, RB AU - Yu, Y AU - Zhang, Z-H AU - Wei, S-G PY - 2009/06/24/ UR - http://dx.doi.org/10.1038/clpt.2009.117 ER -