Differential MR/GR Activation in Mice Results in Emotional States Beneficial or Impairing for Cognition. Export

@article{citeulike:1585486, abstract = {Corticosteroids regulate stress response and influence emotion, learning, and memory via two receptors in the brain, the high-affinity mineralocorticoid (MR) and low-affinity glucocorticoid receptor (GR). We test the hypothesis that MR- and GR-mediated effects interact in emotion and cognition when a novel situation is encountered that is relevant for a learning process. By adrenalectomy and additional constant corticosterone supplement we obtained four groups of male C57BL/6J mice with differential chronic MR and GR activations. Using a hole board task, we found that mice with continuous predominant MR and moderate GR activations were fast learners that displayed low anxiety and arousal together with high directed explorative behavior. Progressive corticosterone concentrations with predominant action via GR induced strong emotional arousal at the expense of cognitive performance. These findings underline the importance of a balanced MR/GR system for emotional and cognitive functioning that is critical for mental health.}, address = {Gorlaeus Lab, Division of Medical Pharmacology, LACDR/LUMC, Leiden University, Einsteinweg 55, 2300 Leiden, The Netherlands.}, author = {Brinks, V. and H van der Mark, M. and de Kloet, E. R. and S Oitzl, M.}, citeulike-article-id = {1585486}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/17710249}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=17710249}, issn = {1687-5443}, journal = {Neural Plast}, posted-at = {2007-08-23 14:13:48}, priority = {4}, title = {Differential MR/GR Activation in Mice Results in Emotional States Beneficial or Impairing for Cognition.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/17710249}, year = {2007} }

TY - JOUR ID - citeulike:1585486 L3 - citeulike-article-id:1585486 N2 - Corticosteroids regulate stress response and influence emotion, learning, and memory via two receptors in the brain, the high-affinity mineralocorticoid (MR) and low-affinity glucocorticoid receptor (GR). We test the hypothesis that MR- and GR-mediated effects interact in emotion and cognition when a novel situation is encountered that is relevant for a learning process. By adrenalectomy and additional constant corticosterone supplement we obtained four groups of male C57BL/6J mice with differential chronic MR and GR activations. Using a hole board task, we found that mice with continuous predominant MR and moderate GR activations were fast learners that displayed low anxiety and arousal together with high directed explorative behavior. Progressive corticosterone concentrations with predominant action via GR induced strong emotional arousal at the expense of cognitive performance. These findings underline the importance of a balanced MR/GR system for emotional and cognitive functioning that is critical for mental health. JF - Neural Plast SN - 1687-5443 AD - Gorlaeus Lab, Division of Medical Pharmacology, LACDR/LUMC, Leiden University, Einsteinweg 55, 2300 Leiden, The Netherlands. TI - Differential MR/GR Activation in Mice Results in Emotional States Beneficial or Impairing for Cognition. AU - Brinks, V AU - H van der Mark, M AU - de Kloet, ER AU - S Oitzl, M PY - 2007/// UR - http://view.ncbi.nlm.nih.gov/pubmed/17710249 ER -