Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice.

@article{citeulike:2358683, abstract = {Many neuroactive steroids (NS) demonstrate neurotrophic and neuroprotective actions, including protection against apoptosis via Bcl-2 protein. NS are altered in post-mortem brain tissue from subjects with bipolar disorder, and several agents with efficacy in mania elevate NS in rodents. We therefore hypothesized that lithium and valproate may elevate NS, and compensatory NS increases may occur in Bcl-2 knockout mice. NS levels (allopregnanolone, pregnenolone) were determined in frontal cortex by negative ion chemical ionization gas chromatography/mass spectrometry in male Wistar Kyoto rats treated chronically with lithium, valproate, or vehicle. NS were also investigated in heterozygous Bcl-2 knockout mice. Allopregnanolone levels are significantly elevated in lithium-treated (p<0.05), but not in valproate-treated, rats. Pregnenolone levels also tend to be higher following lithium treatment (p=0.09). Knockout of Bcl-2 significantly increases pregnenolone levels in mice (p<0.01), while allopregnanolone levels are unaltered. NS induction may be relevant to mechanisms contributing to lithium therapeutic efficacy and neuroprotection.}, address = {Durham Veterans Affairs Medical Center, Durham, NC, USA.}, author = {Marx, Christine E E. and Yuan, Peixiong and Kilts, Jason D D. and Madison, Roger D D. and Shampine, Lawrence J J. and Manji, Husseini K K.}, citeulike-article-id = {2358683}, doi = {10.1017/S1461145708008444}, issn = {1461-1457}, journal = {Int J Neuropsychopharmacol}, keywords = {iliad}, month = {February}, pages = {1--6}, posted-at = {2008-02-10 00:44:11}, priority = {2}, title = {Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice.}, url = {http://dx.doi.org/10.1017/S1461145708008444}, year = {2008} }

TY - JOUR ID - citeulike:2358683 L3 - citeulike-article-id:2358683 N2 - Many neuroactive steroids (NS) demonstrate neurotrophic and neuroprotective actions, including protection against apoptosis via Bcl-2 protein. NS are altered in post-mortem brain tissue from subjects with bipolar disorder, and several agents with efficacy in mania elevate NS in rodents. We therefore hypothesized that lithium and valproate may elevate NS, and compensatory NS increases may occur in Bcl-2 knockout mice. NS levels (allopregnanolone, pregnenolone) were determined in frontal cortex by negative ion chemical ionization gas chromatography/mass spectrometry in male Wistar Kyoto rats treated chronically with lithium, valproate, or vehicle. NS were also investigated in heterozygous Bcl-2 knockout mice. Allopregnanolone levels are significantly elevated in lithium-treated (p<0.05), but not in valproate-treated, rats. Pregnenolone levels also tend to be higher following lithium treatment (p=0.09). Knockout of Bcl-2 significantly increases pregnenolone levels in mice (p<0.01), while allopregnanolone levels are unaltered. NS induction may be relevant to mechanisms contributing to lithium therapeutic efficacy and neuroprotection. JF - Int J Neuropsychopharmacol SN - 1461-1457 AD - Durham Veterans Affairs Medical Center, Durham, NC, USA. EP - 6 TI - Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice. SP - 1 KW - iliad AU - Marx, Christine E AU - Yuan, Peixiong AU - Kilts, Jason D AU - Madison, Roger D AU - Shampine, Lawrence J AU - Manji, Husseini K PY - 2008/02/08/ UR - http://dx.doi.org/10.1017/S1461145708008444 ER -