Neurosteroids as modulators of neurogenesis and neuronal survival.

@article{citeulike:3199911, abstract = {Neurons and glia in the central nervous system express the necessary enzymes for the synthesis of neurosteroids that are produced in concentrations high enough to exert paracrine effects. Synthesis of brain neurosteroids declines with age, during stressful conditions (including major depression, chronic psychological stress), and in chronic inflammatory and neurodegenerative diseases. Recent reports associate the decrease of brain neurosteroids to neuronal dysfunction and degeneration. This review summarizes the recent findings on how the most studied neurosteroids (dehydroepiandrosterone, pregnenolone and their sulphate esters, progesterone and allopregnanolone) affect neuronal survival, neurite outgrowth and neurogenesis; furthermore, this review discusses potential applications of these neurosteroids in the therapeutic management of neurodegenerative conditions, including that of age-related brain atrophy.}, address = {Department of Pharmacology, School of Medicine, University of Crete, Heraklion 71003, Greece.}, author = {Charalampopoulos, Ioannis and Remboutsika, Eumorphia and Margioris, Andrew N N. and Gravanis, Achille}, citeulike-article-id = {3199911}, doi = {10.1016/j.tem.2008.07.004}, issn = {1043-2760}, journal = {Trends in endocrinology and metabolism: TEM}, month = {September}, posted-at = {2008-09-06 19:28:44}, priority = {2}, title = {Neurosteroids as modulators of neurogenesis and neuronal survival.}, url = {http://dx.doi.org/10.1016/j.tem.2008.07.004}, year = {2008} }

TY - JOUR ID - citeulike:3199911 L3 - citeulike-article-id:3199911 N2 - Neurons and glia in the central nervous system express the necessary enzymes for the synthesis of neurosteroids that are produced in concentrations high enough to exert paracrine effects. Synthesis of brain neurosteroids declines with age, during stressful conditions (including major depression, chronic psychological stress), and in chronic inflammatory and neurodegenerative diseases. Recent reports associate the decrease of brain neurosteroids to neuronal dysfunction and degeneration. This review summarizes the recent findings on how the most studied neurosteroids (dehydroepiandrosterone, pregnenolone and their sulphate esters, progesterone and allopregnanolone) affect neuronal survival, neurite outgrowth and neurogenesis; furthermore, this review discusses potential applications of these neurosteroids in the therapeutic management of neurodegenerative conditions, including that of age-related brain atrophy. JF - Trends in endocrinology and metabolism: TEM SN - 1043-2760 AD - Department of Pharmacology, School of Medicine, University of Crete, Heraklion 71003, Greece. TI - Neurosteroids as modulators of neurogenesis and neuronal survival. AU - Charalampopoulos, Ioannis AU - Remboutsika, Eumorphia AU - Margioris, Andrew N AU - Gravanis, Achille PY - 2008/09/02/ UR - http://dx.doi.org/10.1016/j.tem.2008.07.004 ER -