Targeting brain angiotensin and corticotrophin-releasing hormone systems interaction for the treatment of mood and alcohol use disorders. Export

@article{citeulike:3199912, abstract = {The brain renin-angiotensin system (RAS) participates importantly in the regulation of endocrine, autonomic, and behavioral response to stress. Recent data indicate that central action of AT(1) receptor antagonists can reduce anxiety symptoms in experimental animals. Furthermore, central inhibition of RAS activity decreases ethanol intake in an animal model of alcoholism. Pathological anxiety responses and the development of substance dependence are both critically mediated through corticotrophin-releasing hormone (CRH) systems, and the RAS is positioned to interact both with hypothalamic as well as extrahypothalamic CRH systems. The thesis of this paper is that the RAS is part of the neurochemical dysregulation underlying negative affective states, anxiety disorders, and ethanol dependence and that medications targeting the RAS should be considered to augment the treatment of these disorders.}, address = {Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892-1108, USA. wolfgang.sommer@mail.nih.gov}, author = {Sommer, W. H. and Saavedra, J. M.}, citeulike-article-id = {3199912}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s00109-008-0333-3}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18449521}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18449521}, doi = {10.1007/s00109-008-0333-3}, issn = {0946-2716}, journal = {Journal of molecular medicine (Berlin, Germany)}, month = {June}, number = {6}, pages = {723--728}, posted-at = {2008-09-06 19:28:45}, priority = {2}, title = {Targeting brain angiotensin and corticotrophin-releasing hormone systems interaction for the treatment of mood and alcohol use disorders.}, url = {http://dx.doi.org/10.1007/s00109-008-0333-3}, volume = {86}, year = {2008} }

TY - JOUR ID - citeulike:3199912 L3 - citeulike-article-id:3199912 N2 - The brain renin-angiotensin system (RAS) participates importantly in the regulation of endocrine, autonomic, and behavioral response to stress. Recent data indicate that central action of AT(1) receptor antagonists can reduce anxiety symptoms in experimental animals. Furthermore, central inhibition of RAS activity decreases ethanol intake in an animal model of alcoholism. Pathological anxiety responses and the development of substance dependence are both critically mediated through corticotrophin-releasing hormone (CRH) systems, and the RAS is positioned to interact both with hypothalamic as well as extrahypothalamic CRH systems. The thesis of this paper is that the RAS is part of the neurochemical dysregulation underlying negative affective states, anxiety disorders, and ethanol dependence and that medications targeting the RAS should be considered to augment the treatment of these disorders. IS - 6 JF - Journal of molecular medicine (Berlin, Germany) SN - 0946-2716 AD - Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892-1108, USA. wolfgang.sommer@mail.nih.gov EP - 728 TI - Targeting brain angiotensin and corticotrophin-releasing hormone systems interaction for the treatment of mood and alcohol use disorders. VL - 86 SP - 723 AU - Sommer, WH AU - Saavedra, JM PY - 2008/06// UR - http://dx.doi.org/10.1007/s00109-008-0333-3 ER -