Intravenous grafts recapitulate the neurorestoration afforded by intracerebrally delivered multipotent adult progenitor cells in neonatal hypoxic-ischemic rats. Export

@article{citeulike:5781378, abstract = {Once hypoxic-ischemic (HI) injury ensues in the human neonate at birth, the resulting brain damage lasts throughout the individual's lifetime, as no ameliorative treatments are currently available. We have recently shown that intracerebral transplantation of multipotent adult progenitor cells (MAPCs) results in behavioral improvement and reduction in ischemic cell loss in neonatal rat HI-injury model. In an attempt to advance this cellular therapy to the clinic, we explored the more practical and less invasive intravenous administration of MAPCs. Seven-day-old Sprague-Dawley rats were initially subjected to unilateral HI injury, then 7 days later received intracerebral or intravenous injections of allogeneic rat MAPCs. On post-transplantation days 7 and 14, the animals that received MAPCs via the intracerebral or intravenous route exhibited improved motor and neurologic scores compared with those that received vehicle infusion alone. Immunohistochemical evaluations at day 14 after transplantation revealed that both intracerebrally and intravenously transplanted MAPCs were detected in the ischemic hippocampal area. The degree of hippocampal cell preservation was almost the same in the two treatment groups and greater than that in the vehicle group. These results show that intravenous delivery of MAPCs is a feasible and efficacious cell therapy with potential for clinical use.}, author = {Yasuhara, Takao and Hara, Koichi and Maki, Mina and Mays, Robert W. and Deans, Robert J. and Hess, David C. and Carroll, James E. and Borlongan, Cesar V.}, citeulike-article-id = {5781378}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/jcbfm.2008.68}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18594556}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18594556}, doi = {10.1038/jcbfm.2008.68}, issn = {1559-7016}, journal = {Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism}, keywords = {\_cell, adult, adult\_progenitor, brain\_damage, cell\_preservation, cellular\_therapy, evaluations, hypoxia, infusion, intravenous, intravenous\_administration, intravenous\_injections, intravenous\_route, intrecerebral, ischemia, mapcs, multipotent, neonatal, neonate, neurologic, neuroregeneration, rat, seven\_day, sprague\_dawley\_rats, transplantation, treatment\_groups, vehicle\_group}, month = {November}, number = {11}, pages = {1804--1810}, posted-at = {2009-09-14 14:56:31}, priority = {3}, title = {Intravenous grafts recapitulate the neurorestoration afforded by intracerebrally delivered multipotent adult progenitor cells in neonatal hypoxic-ischemic rats.}, url = {http://dx.doi.org/10.1038/jcbfm.2008.68}, volume = {28}, year = {2008} }

TY - JOUR ID - citeulike:5781378 L3 - citeulike-article-id:5781378 N2 - Once hypoxic-ischemic (HI) injury ensues in the human neonate at birth, the resulting brain damage lasts throughout the individual's lifetime, as no ameliorative treatments are currently available. We have recently shown that intracerebral transplantation of multipotent adult progenitor cells (MAPCs) results in behavioral improvement and reduction in ischemic cell loss in neonatal rat HI-injury model. In an attempt to advance this cellular therapy to the clinic, we explored the more practical and less invasive intravenous administration of MAPCs. Seven-day-old Sprague-Dawley rats were initially subjected to unilateral HI injury, then 7 days later received intracerebral or intravenous injections of allogeneic rat MAPCs. On post-transplantation days 7 and 14, the animals that received MAPCs via the intracerebral or intravenous route exhibited improved motor and neurologic scores compared with those that received vehicle infusion alone. Immunohistochemical evaluations at day 14 after transplantation revealed that both intracerebrally and intravenously transplanted MAPCs were detected in the ischemic hippocampal area. The degree of hippocampal cell preservation was almost the same in the two treatment groups and greater than that in the vehicle group. These results show that intravenous delivery of MAPCs is a feasible and efficacious cell therapy with potential for clinical use. IS - 11 JF - Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism SN - 1559-7016 EP - 1810 TI - Intravenous grafts recapitulate the neurorestoration afforded by intracerebrally delivered multipotent adult progenitor cells in neonatal hypoxic-ischemic rats. VL - 28 SP - 1804 KW - _cell KW - adult KW - adult_progenitor KW - brain_damage KW - cell_preservation KW - cellular_therapy KW - evaluations KW - hypoxia KW - infusion KW - intravenous KW - intravenous_administration KW - intravenous_injections KW - intravenous_route KW - intrecerebral KW - ischemia KW - mapcs KW - multipotent KW - neonatal KW - neonate KW - neurologic KW - neuroregeneration KW - rat KW - seven_day KW - sprague_dawley_rats KW - transplantation KW - treatment_groups KW - vehicle_group AU - Yasuhara, Takao AU - Hara, Koichi AU - Maki, Mina AU - Mays, Robert AU - Deans, Robert AU - Hess, David AU - Carroll, James AU - Borlongan, Cesar PY - 2008/11// UR - http://dx.doi.org/10.1038/jcbfm.2008.68 ER -