JAK-STAT Signal Inhibition Regulates Competition in the Drosophila Testis Stem Cell Niche Export

@article{citeulike:5876449, abstract = {Adult stem cells often reside in local microenvironments, or niches. Although niches can contain multiple types of stem cells, the coordinate regulation of stem cell behavior is poorly understood. In the Drosophila testis, Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling is directly required for maintenance of the resident germline and somatic stem cells. We found that the JAK-STAT signaling target and inhibitor Suppressor of cytokine signaling 36E (SOCS36E) is required for germline stem cell maintenance. SOCS36E suppresses JAK-STAT signaling specifically in the somatic stem cells, preventing them from displacing neighboring germline stem cells in a manner that depends on the adhesion protein integrin. Thus, in niches housing multiple stem cell types, negative feedback loops can modulate signaling, preventing one stem cell population from outcompeting the other. 10.1126/science.1176817}, author = {Issigonis, Melanie and Tulina, Natalia and de Cuevas, Margaret and Brawley, Crista and Sandler, Laurel and Matunis, Erika}, citeulike-article-id = {5876449}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1176817}, citeulike-linkout-1 = {http://www.sciencemag.org/content/326/5949/153.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/326/5949/153.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19797664}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19797664}, day = {2}, doi = {10.1126/science.1176817}, journal = {Science}, keywords = {activator, drosophila, germline, inhibition, jak-stat, kinase, negative\_feedback\_loops, niches, signal\_transducer, stem\_cell, target}, month = {October}, number = {5949}, pages = {153--156}, posted-at = {2009-10-12 11:57:36}, priority = {1}, title = {JAK-STAT Signal Inhibition Regulates Competition in the Drosophila Testis Stem Cell Niche}, url = {http://dx.doi.org/10.1126/science.1176817}, volume = {326}, year = {2009} }

TY - JOUR ID - citeulike:5876449 L3 - citeulike-article-id:5876449 N2 - Adult stem cells often reside in local microenvironments, or niches. Although niches can contain multiple types of stem cells, the coordinate regulation of stem cell behavior is poorly understood. In the Drosophila testis, Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling is directly required for maintenance of the resident germline and somatic stem cells. We found that the JAK-STAT signaling target and inhibitor Suppressor of cytokine signaling 36E (SOCS36E) is required for germline stem cell maintenance. SOCS36E suppresses JAK-STAT signaling specifically in the somatic stem cells, preventing them from displacing neighboring germline stem cells in a manner that depends on the adhesion protein integrin. Thus, in niches housing multiple stem cell types, negative feedback loops can modulate signaling, preventing one stem cell population from outcompeting the other. 10.1126/science.1176817 IS - 5949 JF - Science EP - 156 TI - JAK-STAT Signal Inhibition Regulates Competition in the Drosophila Testis Stem Cell Niche VL - 326 SP - 153 KW - activator KW - drosophila KW - germline KW - inhibition KW - jak-stat KW - kinase KW - negative_feedback_loops KW - niches KW - signal_transducer KW - stem_cell KW - target AU - Issigonis, Melanie AU - Tulina, Natalia AU - de Cuevas, Margaret AU - Brawley, Crista AU - Sandler, Laurel AU - Matunis, Erika PY - 2009/10/02/ UR - http://dx.doi.org/10.1126/science.1176817 ER -