Prenatal lipopolysaccharide exposure affects maternal behavior and male offspring sexual behavior in adulthood. Export

@article{citeulike:6066963, abstract = {OBJECTIVE: This study investigates the effects of prenatal lipopolysaccharide (LPS) exposure on the maternal behavior of pregnant rats and the physical development and sexual behavior of their male offspring in adulthood. METHODS: For two experiments, pregnant rats were injected with LPS (250 microg/kg, i.p.) on gestation day (GD) 21. In the first experiment, the maternal behavior (postnatal day, PND, 6) and the dam's open-field general activity (PND7) were evaluated. In the second experiment, the maternal pre- and postnatal parameters, the pup's development, the offspring's sexual behavior in adulthood, and the pup's organ weights were assessed. RESULTS: Compared to the control group, the LPS-treated dams presented reduced maternal behavior, decreased general activity, a smaller body weight difference between GD21 and PND1, a greater number of perinatal deaths, and smaller litters. For the male pups, LPS treatment resulted in a decreased body weight on PND2, whereas the anogenital distance and the day of testis descent were not modified. The male sexual behavior was impaired by prenatal LPS. Particularly the number of ejaculating animals was reduced. The testis weight was also lower in the prenatally LPS-treated rats than in the control rats. CONCLUSION: We propose that prenatal LPS exposure on GD21 acts as an imprinting factor that interferes with the programming of brain sexual determination in offspring.}, author = {Bernardi, Maria M. and Kirsten, Thiago B. and Matsuoka, Suzana M. and Teodorov, Elizabeth and Habr, Soraya F. and Penteado, Sandra H. and Palermo-Neto, Jo\~{a}o}, citeulike-article-id = {6066963}, citeulike-linkout-0 = {http://dx.doi.org/10.1159/000243085}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19816057}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19816057}, doi = {10.1159/000243085}, issn = {1423-0216}, journal = {Neuroimmunomodulation}, keywords = {lipopolysaccharide, lps, lps\_exposure, matenal\_behaviour, perinatal\_deaths, pregnancy, pregnant\_rats, rat, rats, sexual\_behaviour}, number = {1}, pages = {47--55}, posted-at = {2009-11-04 08:17:11}, priority = {2}, title = {Prenatal lipopolysaccharide exposure affects maternal behavior and male offspring sexual behavior in adulthood.}, url = {http://dx.doi.org/10.1159/000243085}, volume = {17}, year = {2010} }

TY - JOUR ID - citeulike:6066963 L3 - citeulike-article-id:6066963 N2 - OBJECTIVE: This study investigates the effects of prenatal lipopolysaccharide (LPS) exposure on the maternal behavior of pregnant rats and the physical development and sexual behavior of their male offspring in adulthood. METHODS: For two experiments, pregnant rats were injected with LPS (250 microg/kg, i.p.) on gestation day (GD) 21. In the first experiment, the maternal behavior (postnatal day, PND, 6) and the dam's open-field general activity (PND7) were evaluated. In the second experiment, the maternal pre- and postnatal parameters, the pup's development, the offspring's sexual behavior in adulthood, and the pup's organ weights were assessed. RESULTS: Compared to the control group, the LPS-treated dams presented reduced maternal behavior, decreased general activity, a smaller body weight difference between GD21 and PND1, a greater number of perinatal deaths, and smaller litters. For the male pups, LPS treatment resulted in a decreased body weight on PND2, whereas the anogenital distance and the day of testis descent were not modified. The male sexual behavior was impaired by prenatal LPS. Particularly the number of ejaculating animals was reduced. The testis weight was also lower in the prenatally LPS-treated rats than in the control rats. CONCLUSION: We propose that prenatal LPS exposure on GD21 acts as an imprinting factor that interferes with the programming of brain sexual determination in offspring. IS - 1 JF - Neuroimmunomodulation SN - 1423-0216 EP - 55 TI - Prenatal lipopolysaccharide exposure affects maternal behavior and male offspring sexual behavior in adulthood. VL - 17 SP - 47 KW - lipopolysaccharide KW - lps KW - lps_exposure KW - matenal_behaviour KW - perinatal_deaths KW - pregnancy KW - pregnant_rats KW - rat KW - rats KW - sexual_behaviour AU - Bernardi, Maria AU - Kirsten, Thiago AU - Matsuoka, Suzana AU - Teodorov, Elizabeth AU - Habr, Soraya AU - Penteado, Sandra AU - Palermo-Neto, João PY - 2010/// UR - http://dx.doi.org/10.1159/000243085 ER -