A novel therapy for nocturnal polyuria: a double-blind randomized trial of frusemide against placebo. Export

@article{citeulike:1804071, abstract = {OBJECTIVE: To report a randomized, double-blind, placebo-controlled trial of an afternoon dose of the diuretic frusemide, used to establish an early evening diuresis and so diminish nocturnal voiding frequency and voided volume in elderly men presenting with lower urinary tract symptoms (LUTS). PATIENTS AND METHODS: After a 2-week placebo run-in period, 49 men aged > 50 years were randomized to receive 40 mg of frusemide or placebo, taken 6 h before their usual bedtime. Day and night-time frequency and voided volume during the run-in and treatment periods were compared between the placebo and frusemide groups. RESULTS: In the 43 men completing the study, there was a significant reduction in night-time frequency (-0.5 and 0) and percentage night-time voided volume (-18\% and 0\%) in those taking frusemide compared with placebo. Of patients on active treatment, seven of 19 had a reduction in night-time frequency of > or = 1, compared with only one of 20 on placebo, and 14 of 21 felt that frusemide had helped their nocturia, compared with only five of 22 on placebo. CONCLUSION: Men with LUTS whose most prominent symptom is nocturia should complete a frequency-volume chart. In those with nocturnal polyuria, 40 mg of frusemide resulted in a significant reduction in night-time frequency and percentage voided volume.}, address = {Department of Urology, The Royal London Hospital, UK.}, author = {Reynard, J. M. and Cannon, A. and Yang, Q. and Abrams, P.}, citeulike-article-id = {1804071}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9488061}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9488061}, comment = {Discusses Lasix 6hr before HS}, issn = {0007-1331}, journal = {Br J Urol}, keywords = {dosing, lasix}, month = {February}, number = {2}, pages = {215--218}, posted-at = {2007-10-22 05:38:46}, priority = {4}, title = {A novel therapy for nocturnal polyuria: a double-blind randomized trial of frusemide against placebo.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9488061}, volume = {81}, year = {1998} }

TY - JOUR ID - citeulike:1804071 L3 - citeulike-article-id:1804071 N2 - OBJECTIVE: To report a randomized, double-blind, placebo-controlled trial of an afternoon dose of the diuretic frusemide, used to establish an early evening diuresis and so diminish nocturnal voiding frequency and voided volume in elderly men presenting with lower urinary tract symptoms (LUTS). PATIENTS AND METHODS: After a 2-week placebo run-in period, 49 men aged > 50 years were randomized to receive 40 mg of frusemide or placebo, taken 6 h before their usual bedtime. Day and night-time frequency and voided volume during the run-in and treatment periods were compared between the placebo and frusemide groups. RESULTS: In the 43 men completing the study, there was a significant reduction in night-time frequency (-0.5 and 0) and percentage night-time voided volume (-18% and 0%) in those taking frusemide compared with placebo. Of patients on active treatment, seven of 19 had a reduction in night-time frequency of > or = 1, compared with only one of 20 on placebo, and 14 of 21 felt that frusemide had helped their nocturia, compared with only five of 22 on placebo. CONCLUSION: Men with LUTS whose most prominent symptom is nocturia should complete a frequency-volume chart. In those with nocturnal polyuria, 40 mg of frusemide resulted in a significant reduction in night-time frequency and percentage voided volume. IS - 2 JF - Br J Urol SN - 0007-1331 AD - Department of Urology, The Royal London Hospital, UK. EP - 218 TI - A novel therapy for nocturnal polyuria: a double-blind randomized trial of frusemide against placebo. VL - 81 SP - 215 KW - dosing KW - lasix N1 - Discusses Lasix 6hr before HS AU - Reynard, JM AU - Cannon, A AU - Yang, Q AU - Abrams, P PY - 1998/02// UR - http://view.ncbi.nlm.nih.gov/pubmed/9488061 ER -