Stability and flexibility of epigenetic gene regulation in mammalian development Export

@article{citeulike:1323462, abstract = {During development, cells start in a pluripotent state, from which they can differentiate into many cell types, and progressively develop a narrower potential. Their gene-expression programmes become more defined, restricted and, potentially, 'locked in'. Pluripotent stem cells express genes that encode a set of core transcription factors, while genes that are required later in development are repressed by histone marks, which confer short-term, and therefore flexible, epigenetic silencing. By contrast, the methylation of DNA confers long-term epigenetic silencing of particular sequences — transposons, imprinted genes and pluripotency-associated genes — in somatic cells. Long-term silencing can be reprogrammed by demethylation of DNA, and this process might involve DNA repair. It is not known whether any of the epigenetic marks has a primary role in determining cell and lineage commitment during development.}, author = {Reik, Wolf}, citeulike-article-id = {1323462}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature05918}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature05918}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17522676}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17522676}, day = {23}, doi = {10.1038/nature05918}, issn = {0028-0836}, journal = {Nature}, keywords = {development, epigenetics, flexibility, review, stability}, month = {May}, number = {7143}, pages = {425--432}, posted-at = {2008-09-26 16:54:43}, priority = {0}, publisher = {Nature Publishing Group}, title = {Stability and flexibility of epigenetic gene regulation in mammalian development}, url = {http://dx.doi.org/10.1038/nature05918}, volume = {447}, year = {2007} }

TY - JOUR ID - citeulike:1323462 L3 - citeulike-article-id:1323462 N2 - During development, cells start in a pluripotent state, from which they can differentiate into many cell types, and progressively develop a narrower potential. Their gene-expression programmes become more defined, restricted and, potentially, 'locked in'. Pluripotent stem cells express genes that encode a set of core transcription factors, while genes that are required later in development are repressed by histone marks, which confer short-term, and therefore flexible, epigenetic silencing. By contrast, the methylation of DNA confers long-term epigenetic silencing of particular sequences — transposons, imprinted genes and pluripotency-associated genes — in somatic cells. Long-term silencing can be reprogrammed by demethylation of DNA, and this process might involve DNA repair. It is not known whether any of the epigenetic marks has a primary role in determining cell and lineage commitment during development. IS - 7143 JF - Nature SN - 0028-0836 EP - 432 TI - Stability and flexibility of epigenetic gene regulation in mammalian development PB - Nature Publishing Group VL - 447 SP - 425 KW - development KW - epigenetics KW - flexibility KW - review KW - stability AU - Reik, Wolf PY - 2007/05/23/ UR - http://dx.doi.org/10.1038/nature05918 ER -