Reprogramming somatic cells towards pluripotency by defined factors. Export

@article{citeulike:2328841, abstract = {The recent years have seen great advances in reversal of programming of differentiated somatic cells towards pluripotency by methods not involving nuclear transfer. Some of these may present a first step on the way to individual-based cell therapy without the problems connected to collection of mammalian unfertilised oocytes. Although differentiation of cells involves complex genetic and epigenetic changes, it is now possible to generate cells with many properties of pluripotent embryonic stem cells by retroviral transduction of differentiated cells with only four transcription factors: Oct3/4, Sox2, Klf4 and c-Myc. The re-programmed cells contribute to live chimeric mice and are transmitted via the germline.}, address = {Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.}, author = {Lewitzky, M. and Yamanaka, S.}, citeulike-article-id = {2328841}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.copbio.2007.09.007}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18024106}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18024106}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6VRV-4R5G83T-1/1/78be66b669cbe0af7c2e591726ef97ba}, doi = {10.1016/j.copbio.2007.09.007}, issn = {0958-1669}, journal = {Curr Opin Biotechnol}, keywords = {c-myc, es, esc, klf4, oct4, pluripotency, reprogramming, sox2, stemness}, month = {October}, number = {5}, pages = {467--473}, posted-at = {2008-10-14 20:54:33}, priority = {0}, title = {Reprogramming somatic cells towards pluripotency by defined factors.}, url = {http://dx.doi.org/10.1016/j.copbio.2007.09.007}, volume = {18}, year = {2007} }

TY - JOUR ID - citeulike:2328841 L3 - citeulike-article-id:2328841 N2 - The recent years have seen great advances in reversal of programming of differentiated somatic cells towards pluripotency by methods not involving nuclear transfer. Some of these may present a first step on the way to individual-based cell therapy without the problems connected to collection of mammalian unfertilised oocytes. Although differentiation of cells involves complex genetic and epigenetic changes, it is now possible to generate cells with many properties of pluripotent embryonic stem cells by retroviral transduction of differentiated cells with only four transcription factors: Oct3/4, Sox2, Klf4 and c-Myc. The re-programmed cells contribute to live chimeric mice and are transmitted via the germline. IS - 5 JF - Curr Opin Biotechnol SN - 0958-1669 AD - Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. EP - 473 TI - Reprogramming somatic cells towards pluripotency by defined factors. VL - 18 SP - 467 KW - c-myc KW - es KW - esc KW - klf4 KW - oct4 KW - pluripotency KW - reprogramming KW - sox2 KW - stemness AU - Lewitzky, M AU - Yamanaka, S PY - 2007/10// UR - http://dx.doi.org/10.1016/j.copbio.2007.09.007 ER -