The evolutionary dynamics of alpha-satellite. Export

@article{citeulike:2714356, abstract = {Alpha-satellite is a family of tandemly repeated sequences found at all normal human centromeres. In addition to its significance for understanding centromere function, alpha-satellite is also a model for concerted evolution, as alpha-satellite repeats are more similar within a species than between species. There are two types of alpha-satellite in the human genome; while both are made up of approximately 171-bp monomers, they can be distinguished by whether monomers are arranged in extremely homogeneous higher-order, multimeric repeat units or exist as more divergent monomeric alpha-satellite that lacks any multimeric periodicity. In this study, as a model to examine the genomic and evolutionary relationships between these two types, we have focused on the chromosome 17 centromeric region that has reached both higher-order and monomeric alpha-satellite in the human genome assembly. Monomeric and higher-order alpha-satellites on chromosome 17 are phylogenetically distinct, consistent with a model in which higher-order evolved independently of monomeric alpha-satellite. Comparative analysis between human chromosome 17 and the orthologous chimpanzee chromosome indicates that monomeric alpha-satellite is evolving at approximately the same rate as the adjacent non-alpha-satellite DNA. However, higher-order alpha-satellite is less conserved, suggesting different evolutionary rates for the two types of alpha-satellite.}, address = {Institute for Genome Sciences \& Policy, Duke University, Durham, North Carolina 27708, USA.}, author = {Rudd, M. K. and Wray, G. A. and Willard, H. F.}, citeulike-article-id = {2714356}, citeulike-linkout-0 = {http://dx.doi.org/10.1101/gr.3810906}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16344556}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16344556}, doi = {10.1101/gr.3810906}, issn = {1088-9051}, journal = {Genome research}, keywords = {alpha-satellite, centromere, evolution}, month = {January}, number = {1}, pages = {88--96}, posted-at = {2008-04-24 22:03:05}, priority = {3}, title = {The evolutionary dynamics of alpha-satellite.}, url = {http://dx.doi.org/10.1101/gr.3810906}, volume = {16}, year = {2006} }

TY - JOUR ID - citeulike:2714356 L3 - citeulike-article-id:2714356 N2 - Alpha-satellite is a family of tandemly repeated sequences found at all normal human centromeres. In addition to its significance for understanding centromere function, alpha-satellite is also a model for concerted evolution, as alpha-satellite repeats are more similar within a species than between species. There are two types of alpha-satellite in the human genome; while both are made up of approximately 171-bp monomers, they can be distinguished by whether monomers are arranged in extremely homogeneous higher-order, multimeric repeat units or exist as more divergent monomeric alpha-satellite that lacks any multimeric periodicity. In this study, as a model to examine the genomic and evolutionary relationships between these two types, we have focused on the chromosome 17 centromeric region that has reached both higher-order and monomeric alpha-satellite in the human genome assembly. Monomeric and higher-order alpha-satellites on chromosome 17 are phylogenetically distinct, consistent with a model in which higher-order evolved independently of monomeric alpha-satellite. Comparative analysis between human chromosome 17 and the orthologous chimpanzee chromosome indicates that monomeric alpha-satellite is evolving at approximately the same rate as the adjacent non-alpha-satellite DNA. However, higher-order alpha-satellite is less conserved, suggesting different evolutionary rates for the two types of alpha-satellite. IS - 1 JF - Genome research SN - 1088-9051 AD - Institute for Genome Sciences & Policy, Duke University, Durham, North Carolina 27708, USA. EP - 96 TI - The evolutionary dynamics of alpha-satellite. VL - 16 SP - 88 KW - alpha-satellite KW - centromere KW - evolution AU - Rudd, MK AU - Wray, GA AU - Willard, HF PY - 2006/01// UR - http://dx.doi.org/10.1101/gr.3810906 ER -