The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression. Export

@article{citeulike:2763042, abstract = {According to the prevailing view, mammalian X chromosomes are enriched in spermatogenesis genes expressed before meiosis and deficient in spermatogenesis genes expressed after meiosis. The paucity of postmeiotic genes on the X chromosome has been interpreted as a consequence of meiotic sex chromosome inactivation (MSCI)--the complete silencing of genes on the XY bivalent at meiotic prophase. Recent studies have concluded that MSCI-initiated silencing persists beyond meiosis and that most genes on the X chromosome remain repressed in round spermatids. Here, we report that 33 multicopy gene families, representing approximately 273 mouse X-linked genes, are expressed in the testis and that this expression is predominantly in postmeiotic cells. RNA FISH and microarray analysis show that the maintenance of X chromosome postmeiotic repression is incomplete. Furthermore, X-linked multicopy genes exhibit a similar degree of expression as autosomal genes. Thus, not only is the mouse X chromosome enriched for spermatogenesis genes functioning before meiosis, but in addition, approximately 18\% of mouse X-linked genes are expressed in postmeiotic cells.}, address = {Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.}, author = {Mueller, Jacob L. and Mahadevaiah, Shantha K. and Park, Peter J. and Warburton, Peter E. and Page, David C. and Turner, James M.}, citeulike-article-id = {2763042}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ng.126}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ng.126}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18454149}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18454149}, doi = {10.1038/ng.126}, issn = {1546-1718}, journal = {Nature genetics}, keywords = {gamete, gametogenesis, germline, inactivation, meiosis, x-chromosome}, month = {June}, number = {6}, pages = {794--799}, posted-at = {2008-05-06 23:38:52}, priority = {4}, title = {The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression.}, url = {http://dx.doi.org/10.1038/ng.126}, volume = {40}, year = {2008} }

TY - JOUR ID - citeulike:2763042 L3 - citeulike-article-id:2763042 N2 - According to the prevailing view, mammalian X chromosomes are enriched in spermatogenesis genes expressed before meiosis and deficient in spermatogenesis genes expressed after meiosis. The paucity of postmeiotic genes on the X chromosome has been interpreted as a consequence of meiotic sex chromosome inactivation (MSCI)--the complete silencing of genes on the XY bivalent at meiotic prophase. Recent studies have concluded that MSCI-initiated silencing persists beyond meiosis and that most genes on the X chromosome remain repressed in round spermatids. Here, we report that 33 multicopy gene families, representing approximately 273 mouse X-linked genes, are expressed in the testis and that this expression is predominantly in postmeiotic cells. RNA FISH and microarray analysis show that the maintenance of X chromosome postmeiotic repression is incomplete. Furthermore, X-linked multicopy genes exhibit a similar degree of expression as autosomal genes. Thus, not only is the mouse X chromosome enriched for spermatogenesis genes functioning before meiosis, but in addition, approximately 18% of mouse X-linked genes are expressed in postmeiotic cells. IS - 6 JF - Nature genetics SN - 1546-1718 AD - Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA. EP - 799 TI - The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression. VL - 40 SP - 794 KW - gamete KW - gametogenesis KW - germline KW - inactivation KW - meiosis KW - x-chromosome AU - Mueller, Jacob AU - Mahadevaiah, Shantha AU - Park, Peter AU - Warburton, Peter AU - Page, David AU - Turner, James PY - 2008/06/04/ UR - http://dx.doi.org/10.1038/ng.126 ER -