Meiotic sex chromosome inactivation in the marsupial Monodelphis domestica. Export

@article{citeulike:2823503, abstract = {In eutherian mammals, the X and Y chromosomes undergo meiotic sex chromosome inactivation (MSCI) during spermatogenesis in males. However, following fertilization, both the paternally (Xp) and maternally (Xm) inherited X chromosomes are active in the inner cell mass of the female blastocyst, and then random inactivation of one X chromosome occurs in each cell, leading to a mosaic pattern of X-chromosome activity in adult female tissues. In contrast, marsupial females show a nonrandom pattern of X chromosome activity, with repression of the Xp in all somatic tissues. Here, we show that MSCI also occurs during spermatogenesis in marsupials in a manner similar to, but more stable than that in eutherians. These findings support the suggestion that MSCI may have provided the basis for an early dosage compensation mechanism in mammals based solely on gametogenic events, and that random X-chromosome inactivation during embryogenesis may have evolved subsequently in eutherian mammals.}, address = {Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249, USA.}, author = {Hornecker, J. L. and Samollow, P. B. and Robinson, E. S. and Vandeberg, J. L. and McCarrey, J. R.}, citeulike-article-id = {2823503}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/dvg.20345}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17987663}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17987663}, doi = {10.1002/dvg.20345}, issn = {1526-954X}, journal = {Genesis (New York, N.Y. : 2000)}, keywords = {evolution, germline, inactivation, marsupial, meiosis, monodelphis, sex, sperm, x-chromosome}, month = {November}, number = {11}, pages = {696--708}, posted-at = {2008-05-22 18:51:49}, priority = {0}, title = {Meiotic sex chromosome inactivation in the marsupial Monodelphis domestica.}, url = {http://dx.doi.org/10.1002/dvg.20345}, volume = {45}, year = {2007} }

TY - JOUR ID - citeulike:2823503 L3 - citeulike-article-id:2823503 N2 - In eutherian mammals, the X and Y chromosomes undergo meiotic sex chromosome inactivation (MSCI) during spermatogenesis in males. However, following fertilization, both the paternally (Xp) and maternally (Xm) inherited X chromosomes are active in the inner cell mass of the female blastocyst, and then random inactivation of one X chromosome occurs in each cell, leading to a mosaic pattern of X-chromosome activity in adult female tissues. In contrast, marsupial females show a nonrandom pattern of X chromosome activity, with repression of the Xp in all somatic tissues. Here, we show that MSCI also occurs during spermatogenesis in marsupials in a manner similar to, but more stable than that in eutherians. These findings support the suggestion that MSCI may have provided the basis for an early dosage compensation mechanism in mammals based solely on gametogenic events, and that random X-chromosome inactivation during embryogenesis may have evolved subsequently in eutherian mammals. IS - 11 JF - Genesis (New York, N.Y. : 2000) SN - 1526-954X AD - Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249, USA. EP - 708 TI - Meiotic sex chromosome inactivation in the marsupial Monodelphis domestica. VL - 45 SP - 696 KW - evolution KW - germline KW - inactivation KW - marsupial KW - meiosis KW - monodelphis KW - sex KW - sperm KW - x-chromosome AU - Hornecker, JL AU - Samollow, PB AU - Robinson, ES AU - Vandeberg, JL AU - McCarrey, JR PY - 2007/11// UR - http://dx.doi.org/10.1002/dvg.20345 ER -