Sister Chromatid Cohesion: A Simple Concept with a Complex Reality. Export

@article{citeulike:3019127, abstract = {In eukaryotes, the process of sister chromatid cohesion holds the two sister chromatids (the replicated chromosomes) together from DNA replication to the onset of chromosome segregation. Cohesion is mediated by cohesin, a four-subunit SMC (structural maintenance of chromosome) complex. Cohesin and cohesion are required for proper chromosome segregation, DNA repair, and gene expression. To carry out these functions, cohesion is regulated by elaborate mechanisms involving a growing list of cohesin auxiliary factors. These factors control the timing and position of cohesin binding to chromatin, activate chromatin-bound cohesin to become cohesive, and orchestrate the orderly dissolution of cohesion. The 45-nm ring-like architecture of soluble cohesin is compatible with dramatically different mechanisms for both chromatin binding and cohesion generation. Solving the mechanism of cohesion and its complex regulation presents significant challenges but offers the potential to provide important insights into higher-order chromosome organization and chromosome biology. Expected final online publication date for the Annual Review of Cell and Developmental Biology Volume 24 is October 06, 2008. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.}, address = {Howard Hughes Medical Institute, Carnegie Institution, Baltimore, Maryland 21218; email: onn@ciwemb.edu.}, author = {Onn, Itay and Heidinger-Pauli, Jill M M. and Guacci, Vincent and Unal, El\c{c}in and Koshland, Douglas E E.}, citeulike-article-id = {3019127}, citeulike-linkout-0 = {http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.cellbio.24.110707.175350}, citeulike-linkout-1 = {http://dx.doi.org/10.1146/annurev.cellbio.24.110707.175350}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18616427}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18616427}, doi = {10.1146/annurev.cellbio.24.110707.175350}, issn = {1081-0706}, journal = {Annual review of cell and developmental biology}, keywords = {chromatid, cohesin, review}, month = {July}, posted-at = {2008-07-18 18:29:45}, priority = {0}, title = {Sister Chromatid Cohesion: A Simple Concept with a Complex Reality.}, url = {http://dx.doi.org/10.1146/annurev.cellbio.24.110707.175350}, year = {2008} }

TY - JOUR ID - citeulike:3019127 L3 - citeulike-article-id:3019127 N2 - In eukaryotes, the process of sister chromatid cohesion holds the two sister chromatids (the replicated chromosomes) together from DNA replication to the onset of chromosome segregation. Cohesion is mediated by cohesin, a four-subunit SMC (structural maintenance of chromosome) complex. Cohesin and cohesion are required for proper chromosome segregation, DNA repair, and gene expression. To carry out these functions, cohesion is regulated by elaborate mechanisms involving a growing list of cohesin auxiliary factors. These factors control the timing and position of cohesin binding to chromatin, activate chromatin-bound cohesin to become cohesive, and orchestrate the orderly dissolution of cohesion. The 45-nm ring-like architecture of soluble cohesin is compatible with dramatically different mechanisms for both chromatin binding and cohesion generation. Solving the mechanism of cohesion and its complex regulation presents significant challenges but offers the potential to provide important insights into higher-order chromosome organization and chromosome biology. Expected final online publication date for the Annual Review of Cell and Developmental Biology Volume 24 is October 06, 2008. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates. JF - Annual review of cell and developmental biology SN - 1081-0706 AD - Howard Hughes Medical Institute, Carnegie Institution, Baltimore, Maryland 21218; email: onn@ciwemb.edu. TI - Sister Chromatid Cohesion: A Simple Concept with a Complex Reality. KW - chromatid KW - cohesin KW - review AU - Onn, Itay AU - Heidinger-Pauli, Jill M AU - Guacci, Vincent AU - Unal, Elçin AU - Koshland, Douglas E PY - 2008/07/10/ UR - http://dx.doi.org/10.1146/annurev.cellbio.24.110707.175350 ER -