Epigenetic reprogramming during early development in mammals. Export

@article{citeulike:3072875, abstract = {Epigenetic modifications serve as an extension of the information content by which the underlying genetic code may be interpreted. These modifications mark genomic regions and act as heritable and stable instructions for the specification of chromatin organisation and structure that dictate transcriptional states. In mammals, DNA methylation and the modification of histones account for the major epigenetic alterations. Two cycles of DNA methylation reprogramming have been characterised. During germ cell development, epigenetic reprogramming of DNA methylation resets parent-of-origin based genomic imprints and restores totipotency to gametes. On fertilisation, the second cycle is triggered resulting in an asymmetric difference between parental genomes. Further epigenetic asymmetry is evident in the establishment of the first two lineages at the blastocyst stage. This differentiative event sets the epigenetic characteristics of the lineages as derivatives of the inner cell mass (somatic) and trophectoderm (extra-embryonic). It is the erasure and subsequent re-tracing of the epigenetic checkpoints that pose the most serious obstacles to somatic nuclear transfer. Elaboration of the mechanisms of these interactions will be invaluable in our fundamental understanding of biological processes and in achieving substantial therapeutic advances.}, address = {Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK.}, author = {Santos, F. and Dean, W.}, citeulike-article-id = {3072875}, citeulike-linkout-0 = {http://dx.doi.org/10.1530/rep.1.00221}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15175501}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15175501}, doi = {10.1530/rep.1.00221}, issn = {1470-1626}, journal = {Reproduction (Cambridge, England)}, keywords = {chromatin, early-mouse-embryo, embryo, epigenetics, reprogramming, review}, month = {June}, number = {6}, pages = {643--651}, posted-at = {2008-08-01 19:31:12}, priority = {0}, title = {Epigenetic reprogramming during early development in mammals.}, url = {http://dx.doi.org/10.1530/rep.1.00221}, volume = {127}, year = {2004} }

TY - JOUR ID - citeulike:3072875 L3 - citeulike-article-id:3072875 N2 - Epigenetic modifications serve as an extension of the information content by which the underlying genetic code may be interpreted. These modifications mark genomic regions and act as heritable and stable instructions for the specification of chromatin organisation and structure that dictate transcriptional states. In mammals, DNA methylation and the modification of histones account for the major epigenetic alterations. Two cycles of DNA methylation reprogramming have been characterised. During germ cell development, epigenetic reprogramming of DNA methylation resets parent-of-origin based genomic imprints and restores totipotency to gametes. On fertilisation, the second cycle is triggered resulting in an asymmetric difference between parental genomes. Further epigenetic asymmetry is evident in the establishment of the first two lineages at the blastocyst stage. This differentiative event sets the epigenetic characteristics of the lineages as derivatives of the inner cell mass (somatic) and trophectoderm (extra-embryonic). It is the erasure and subsequent re-tracing of the epigenetic checkpoints that pose the most serious obstacles to somatic nuclear transfer. Elaboration of the mechanisms of these interactions will be invaluable in our fundamental understanding of biological processes and in achieving substantial therapeutic advances. IS - 6 JF - Reproduction (Cambridge, England) SN - 1470-1626 AD - Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK. EP - 651 TI - Epigenetic reprogramming during early development in mammals. VL - 127 SP - 643 KW - chromatin KW - early-mouse-embryo KW - embryo KW - epigenetics KW - reprogramming KW - review AU - Santos, F AU - Dean, W PY - 2004/06// UR - http://dx.doi.org/10.1530/rep.1.00221 ER -