CCCTC-binding factor: to loop or to bridge. Export

@article{citeulike:3900401, abstract = {Eukaryotic genomes have complex spatial organization in the nucleus. The factors and the mechanisms involved in this organization remain an enigma. Among the many proteins implicated in such a role, the ubiquitous Zn-finger protein CTCF stands out. Here we summarize the evidence placing CTCF in the enviable position of a master organizer of the genome. CTCF can form loops in cis, and can bridge sequences located on different chromosomes in trans. The thousands of CTCF binding sites, identified in recent genome-wide localization studies, and their distribution along the genome further support a crucial role of CTCF as a chromatin organizer.}, author = {Zlatanova, J. and Caiafa, P.}, citeulike-article-id = {3900401}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s00018-009-8647-z}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19137260}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19137260}, citeulike-linkout-3 = {http://www.springerlink.com/content/d3r265w3k1540387}, day = {14}, doi = {10.1007/s00018-009-8647-z}, issn = {1420-9071}, journal = {Cellular and molecular life sciences : CMLS}, keywords = {adp-ribose, adp-ribosylation, ctcf, loop, nuclear-architecture, nuclear-localization, parp1}, month = {January}, posted-at = {2009-06-04 19:04:05}, priority = {0}, title = {CCCTC-binding factor: to loop or to bridge.}, url = {http://dx.doi.org/10.1007/s00018-009-8647-z}, year = {2009} }

TY - JOUR ID - citeulike:3900401 L3 - citeulike-article-id:3900401 N2 - Eukaryotic genomes have complex spatial organization in the nucleus. The factors and the mechanisms involved in this organization remain an enigma. Among the many proteins implicated in such a role, the ubiquitous Zn-finger protein CTCF stands out. Here we summarize the evidence placing CTCF in the enviable position of a master organizer of the genome. CTCF can form loops in cis, and can bridge sequences located on different chromosomes in trans. The thousands of CTCF binding sites, identified in recent genome-wide localization studies, and their distribution along the genome further support a crucial role of CTCF as a chromatin organizer. JF - Cellular and molecular life sciences : CMLS SN - 1420-9071 TI - CCCTC-binding factor: to loop or to bridge. KW - adp-ribose KW - adp-ribosylation KW - ctcf KW - loop KW - nuclear-architecture KW - nuclear-localization KW - parp1 AU - Zlatanova, J AU - Caiafa, P PY - 2009/01/14/ UR - http://dx.doi.org/10.1007/s00018-009-8647-z ER -