Biology, one molecule at a time Export

@article{citeulike:4573371, abstract = {Single-molecule techniques have moved from being a fascinating curiosity to a highlight of life science research. The single-molecule approach to biology offers distinct advantages over the conventional approach of taking bulk measurements; this additional information content usually comes at the cost of the additional complexity. Popular single-molecule methods include optical and magnetic tweezers, atomic force microscopy, tethered particle motion and single-molecule fluorescence spectroscopy; the complement of these methods offers a wide range of spatial and temporal capabilities. These approaches have been instrumental in addressing important biological questions in diverse areas such as protein-DNA interactions, protein folding and the function(s) of membrane proteins.}, author = {Kapanidis, Achillefs N. and Strick, Terence}, citeulike-article-id = {4573371}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tibs.2009.01.008}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0968000409000620}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19362843}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19362843}, doi = {10.1016/j.tibs.2009.01.008}, issn = {09680004}, journal = {Trends in Biochemical Sciences}, keywords = {afm, atomic-force-microscopy, imaging, magnetic-tweezer, microscopy, optical-tweezer, single-molecule, single-molecule-fluorescence-spectroscopy, tethered-particle-motion}, month = {May}, number = {5}, pages = {234--243}, posted-at = {2009-10-26 18:40:52}, priority = {0}, title = {Biology, one molecule at a time}, url = {http://dx.doi.org/10.1016/j.tibs.2009.01.008}, volume = {34}, year = {2009} }

TY - JOUR ID - citeulike:4573371 L3 - citeulike-article-id:4573371 N2 - Single-molecule techniques have moved from being a fascinating curiosity to a highlight of life science research. The single-molecule approach to biology offers distinct advantages over the conventional approach of taking bulk measurements; this additional information content usually comes at the cost of the additional complexity. Popular single-molecule methods include optical and magnetic tweezers, atomic force microscopy, tethered particle motion and single-molecule fluorescence spectroscopy; the complement of these methods offers a wide range of spatial and temporal capabilities. These approaches have been instrumental in addressing important biological questions in diverse areas such as protein-DNA interactions, protein folding and the function(s) of membrane proteins. IS - 5 JF - Trends in Biochemical Sciences SN - 09680004 EP - 243 TI - Biology, one molecule at a time VL - 34 SP - 234 KW - afm KW - atomic-force-microscopy KW - imaging KW - magnetic-tweezer KW - microscopy KW - optical-tweezer KW - single-molecule KW - single-molecule-fluorescence-spectroscopy KW - tethered-particle-motion AU - Kapanidis, Achillefs AU - Strick, Terence PY - 2009/05// UR - http://dx.doi.org/10.1016/j.tibs.2009.01.008 ER -