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Breaching the boundaries that safeguard against repression.by: V. K. Tiwari, S. B. Baylin
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AbstractIn a recent issue of Molecular Cell, Witcher and Emerson (2009) demonstrate that CTCF loss of function, via defective steps in poly (ADP-ribosyl)ation, may predispose key genes in cancer cells to addition of abnormal promoter DNA methylation and silencing.
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