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Breaching the boundaries that safeguard against repression. Export

Molecular cell, Vol. 34, No. 4. (14 May 2009), pp. 395-397.

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adp-ribose adp-ribosylation ctcf epigenetics nuclear-architecture nuclear-localization nucleus parp

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In a recent issue of Molecular Cell, Witcher and Emerson (2009) demonstrate that CTCF loss of function, via defective steps in poly (ADP-ribosyl)ation, may predispose key genes in cancer cells to addition of abnormal promoter DNA methylation and silencing.


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