CTCF: Master Weaver of the Genome Export

@article{citeulike:5041193, abstract = {CTCF is a highly conserved zinc finger protein implicated in diverse regulatory functions, including transcriptional activation/repression, insulation, imprinting, and X chromosome inactivation. Here we re-evaluate data supporting these roles in the context of mechanistic insights provided by recent genome-wide studies and highlight evidence for CTCF-mediated intra- and interchromosomal contacts at several developmentally regulated genomic loci. These analyses support a primary role for CTCF in the global organization of chromatin architecture and suggest that CTCF may be a heritable component of an epigenetic system regulating the interplay between DNA methylation, higher-order chromatin structure, and lineage-specific gene expression.}, author = {Phillips, Jennifer E. and Corces, Victor G.}, citeulike-article-id = {5041193}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cell.2009.06.001}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0092867409006990}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19563753}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19563753}, day = {26}, doi = {10.1016/j.cell.2009.06.001}, issn = {00928674}, journal = {Cell}, keywords = {3d, ctcf, loop}, month = {June}, number = {7}, pages = {1194--1211}, posted-at = {2009-07-06 20:06:31}, priority = {0}, title = {CTCF: Master Weaver of the Genome}, url = {http://dx.doi.org/10.1016/j.cell.2009.06.001}, volume = {137}, year = {2009} }

TY - JOUR ID - citeulike:5041193 L3 - citeulike-article-id:5041193 N2 - CTCF is a highly conserved zinc finger protein implicated in diverse regulatory functions, including transcriptional activation/repression, insulation, imprinting, and X chromosome inactivation. Here we re-evaluate data supporting these roles in the context of mechanistic insights provided by recent genome-wide studies and highlight evidence for CTCF-mediated intra- and interchromosomal contacts at several developmentally regulated genomic loci. These analyses support a primary role for CTCF in the global organization of chromatin architecture and suggest that CTCF may be a heritable component of an epigenetic system regulating the interplay between DNA methylation, higher-order chromatin structure, and lineage-specific gene expression. IS - 7 JF - Cell SN - 00928674 EP - 1211 TI - CTCF: Master Weaver of the Genome VL - 137 SP - 1194 KW - 3d KW - ctcf KW - loop AU - Phillips, Jennifer AU - Corces, Victor PY - 2009/06/26/ UR - http://dx.doi.org/10.1016/j.cell.2009.06.001 ER -