Chromatin organization marks exon-intron structure. Export

@article{citeulike:5663825, abstract = {An increasing body of evidence indicates that transcription and splicing are coupled, and it is accepted that chromatin organization regulates transcription. Little is known about the cross-talk between chromatin structure and exon-intron architecture. By analysis of genome-wide nucleosome-positioning data sets from humans, flies and worms, we found that exons show increased nucleosome-occupancy levels with respect to introns, a finding that we link to differential GC content and nucleosome-disfavoring elements between exons and introns. Analysis of genome-wide chromatin immunoprecipitation data in humans and mice revealed four specific post-translational histone modifications enriched in exons. Our findings indicate that previously described enrichment of H3K36me3 modifications in exons reflects a more fundamental phenomenon, namely increased nucleosome occupancy along exons. Our results suggest an RNA polymerase II-mediated cross-talk between chromatin structure and exon-intron architecture, implying that exon selection may be modulated by chromatin structure.}, author = {Schwartz, Schraga and Meshorer, Eran and Ast, Gil}, citeulike-article-id = {5663825}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nsmb.1659}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nsmb.1659}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19684600}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19684600}, day = {16}, doi = {10.1038/nsmb.1659}, issn = {1545-9985}, journal = {Nature structural \& molecular biology}, keywords = {exon, gc, h3k36me3, intron, nucleosome, nucleosome-positioning, polii}, month = {September}, number = {9}, pages = {990--995}, posted-at = {2009-10-29 21:42:10}, priority = {3}, publisher = {Nature Publishing Group}, title = {Chromatin organization marks exon-intron structure.}, url = {http://dx.doi.org/10.1038/nsmb.1659}, volume = {16}, year = {2009} }

TY - JOUR ID - citeulike:5663825 L3 - citeulike-article-id:5663825 N2 - An increasing body of evidence indicates that transcription and splicing are coupled, and it is accepted that chromatin organization regulates transcription. Little is known about the cross-talk between chromatin structure and exon-intron architecture. By analysis of genome-wide nucleosome-positioning data sets from humans, flies and worms, we found that exons show increased nucleosome-occupancy levels with respect to introns, a finding that we link to differential GC content and nucleosome-disfavoring elements between exons and introns. Analysis of genome-wide chromatin immunoprecipitation data in humans and mice revealed four specific post-translational histone modifications enriched in exons. Our findings indicate that previously described enrichment of H3K36me3 modifications in exons reflects a more fundamental phenomenon, namely increased nucleosome occupancy along exons. Our results suggest an RNA polymerase II-mediated cross-talk between chromatin structure and exon-intron architecture, implying that exon selection may be modulated by chromatin structure. IS - 9 JF - Nature structural & molecular biology SN - 1545-9985 EP - 995 TI - Chromatin organization marks exon-intron structure. PB - Nature Publishing Group VL - 16 SP - 990 KW - exon KW - gc KW - h3k36me3 KW - intron KW - nucleosome KW - nucleosome-positioning KW - polii AU - Schwartz, Schraga AU - Meshorer, Eran AU - Ast, Gil PY - 2009/09/16/ UR - http://dx.doi.org/10.1038/nsmb.1659 ER -