Critical roles for Dicer in the female germline. Export

@article{citeulike:5937886, abstract = {Dicer is an essential component of RNA interference (RNAi) pathways, which have broad functions in gene regulation and genome organization. Probing the consequences of tissue-restricted Dicer loss in mice indicates a critical role for Dicer during meiosis in the female germline. Mouse oocytes lacking Dicer arrest in meiosis I with multiple disorganized spindles and severe chromosome congression defects. Oogenesis and early development are times of significant post-transcriptional regulation, with controlled mRNA storage, translation, and degradation. Our results suggest that Dicer is essential for turnover of a substantial subset of maternal transcripts that are normally lost during oocyte maturation. Furthermore, we find evidence that transposon-derived sequence elements may contribute to the metabolism of maternal transcripts through a Dicer-dependent pathway. Our studies identify Dicer as central to a regulatory network that controls oocyte gene expression programs and that promotes genomic integrity in a cell type notoriously susceptible to aneuploidy.}, author = {Murchison, Elizabeth P. and Stein, Paula and Xuan, Zhenyu and Pan, Hua and Zhang, Michael Q. and Schultz, Richard M. and Hannon, Gregory J.}, citeulike-article-id = {5937886}, citeulike-linkout-0 = {http://dx.doi.org/10.1101/gad.1521307}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17369401}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17369401}, day = {15}, doi = {10.1101/gad.1521307}, issn = {0890-9369}, journal = {Genes \& development}, keywords = {dicer, mirna, oocyte, rnai, sirna, small-rna}, month = {March}, number = {6}, pages = {682--693}, posted-at = {2009-10-13 22:39:13}, priority = {0}, title = {Critical roles for Dicer in the female germline.}, url = {http://dx.doi.org/10.1101/gad.1521307}, volume = {21}, year = {2007} }

TY - JOUR ID - citeulike:5937886 L3 - citeulike-article-id:5937886 N2 - Dicer is an essential component of RNA interference (RNAi) pathways, which have broad functions in gene regulation and genome organization. Probing the consequences of tissue-restricted Dicer loss in mice indicates a critical role for Dicer during meiosis in the female germline. Mouse oocytes lacking Dicer arrest in meiosis I with multiple disorganized spindles and severe chromosome congression defects. Oogenesis and early development are times of significant post-transcriptional regulation, with controlled mRNA storage, translation, and degradation. Our results suggest that Dicer is essential for turnover of a substantial subset of maternal transcripts that are normally lost during oocyte maturation. Furthermore, we find evidence that transposon-derived sequence elements may contribute to the metabolism of maternal transcripts through a Dicer-dependent pathway. Our studies identify Dicer as central to a regulatory network that controls oocyte gene expression programs and that promotes genomic integrity in a cell type notoriously susceptible to aneuploidy. IS - 6 JF - Genes & development SN - 0890-9369 EP - 693 TI - Critical roles for Dicer in the female germline. VL - 21 SP - 682 KW - dicer KW - mirna KW - oocyte KW - rnai KW - sirna KW - small-rna AU - Murchison, Elizabeth AU - Stein, Paula AU - Xuan, Zhenyu AU - Pan, Hua AU - Zhang, Michael AU - Schultz, Richard AU - Hannon, Gregory PY - 2007/03/15/ UR - http://dx.doi.org/10.1101/gad.1521307 ER -