Systems genetics of complex traits in Drosophila melanogaster Export

@article{citeulike:4097910, abstract = {Determining the genetic architecture of complex traits is challenging because phenotypic variation arises from interactions between multiple, environmentally sensitive alleles. We quantified genome-wide transcript abundance and phenotypes for six ecologically relevant traits in D. melanogaster wild-derived inbred lines. We observed 10,096 genetically variable transcripts and high heritabilities for all organismal phenotypes. The transcriptome is highly genetically intercorrelated, forming 241 transcriptional modules. Modules are enriched for transcripts in common pathways, gene ontology categories, tissue-specific expression and transcription factor binding sites. The high degree of transcriptional connectivity allows us to infer genetic networks and the function of predicted genes from annotations of other genes in the network. Regressions of organismal phenotypes on transcript abundance implicate several hundred candidate genes that form modules of biologically meaningful correlated transcripts affecting each phenotype. Overlapping transcripts in modules associated with different traits provide insight into the molecular basis of pleiotropy between complex traits.}, author = {Ayroles, Julien F. and Carbone, Mary A. and Stone, Eric A. and Jordan, Katherine W. and Lyman, Richard F. and Magwire, Michael M. and Rollmann, Stephanie M. and Duncan, Laura H. and Lawrence, Faye and Anholt, Robert R. H. and Mackay, Trudy F. C.}, citeulike-article-id = {4097910}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ng.332}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ng.332}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19234471}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19234471}, day = {22}, doi = {10.1038/ng.332}, issn = {1061-4036}, journal = {Nature Genetics}, keywords = {malaria, summer-journal}, month = {February}, number = {3}, pages = {299--307}, posted-at = {2009-05-24 00:05:32}, priority = {4}, publisher = {Nature Publishing Group}, title = {Systems genetics of complex traits in Drosophila melanogaster}, url = {http://dx.doi.org/10.1038/ng.332}, volume = {41}, year = {2009} }

TY - JOUR ID - citeulike:4097910 L3 - citeulike-article-id:4097910 N2 - Determining the genetic architecture of complex traits is challenging because phenotypic variation arises from interactions between multiple, environmentally sensitive alleles. We quantified genome-wide transcript abundance and phenotypes for six ecologically relevant traits in D. melanogaster wild-derived inbred lines. We observed 10,096 genetically variable transcripts and high heritabilities for all organismal phenotypes. The transcriptome is highly genetically intercorrelated, forming 241 transcriptional modules. Modules are enriched for transcripts in common pathways, gene ontology categories, tissue-specific expression and transcription factor binding sites. The high degree of transcriptional connectivity allows us to infer genetic networks and the function of predicted genes from annotations of other genes in the network. Regressions of organismal phenotypes on transcript abundance implicate several hundred candidate genes that form modules of biologically meaningful correlated transcripts affecting each phenotype. Overlapping transcripts in modules associated with different traits provide insight into the molecular basis of pleiotropy between complex traits. IS - 3 JF - Nature Genetics SN - 1061-4036 EP - 307 TI - Systems genetics of complex traits in Drosophila melanogaster PB - Nature Publishing Group VL - 41 SP - 299 KW - malaria KW - summer-journal AU - Ayroles, Julien AU - Carbone, Mary AU - Stone, Eric AU - Jordan, Katherine AU - Lyman, Richard AU - Magwire, Michael AU - Rollmann, Stephanie AU - Duncan, Laura AU - Lawrence, Faye AU - Anholt, Robert AU - Mackay, Trudy PY - 2009/02/22/ UR - http://dx.doi.org/10.1038/ng.332 ER -