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Long-term dynamics of CA1 hippocampal place codes

by: Yaniv Ziv, Laurie D. Burns, Eric D. Cocker, Elizabeth O. Hamel, Kunal K. Ghosh, Lacey J. Kitch, Abbas E. Gamal, Mark J. Schnitzer
Nat Neurosci, Vol. 16, No. 3. (10 March 2013), pp. 264-266, doi:10.1038/nn.3329  Key: citeulike:12015104

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Abstract

Using Ca(2+) imaging in freely behaving mice that repeatedly explored a familiar environment, we tracked thousands of CA1 pyramidal cells' place fields over weeks. Place coding was dynamic, as each day the ensemble representation of this environment involved a unique subset of cells. However, cells in the ∼15-25% overlap between any two of these subsets retained the same place fields, which sufficed to preserve an accurate spatial representation across weeks.


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