Impact of quorum sensing on fitness of Pseudomonas aeruginosa Export

@article{citeulike:1940604, abstract = {In Pseudomonas aeruginosa , cell–cell communication based on N -acyl-homoserine lactone (AHL) signal molecules (termed quorum sensing) is known to control the production of extracellular virulence factors. Hence, in pathogenic interactions with host organisms, the quorum-sensing (QS) machinery can confer a selective advantage on P. aeruginosa . However, as shown by transcriptomic and proteomic studies, many intracellular metabolic functions are also regulated by quorum sensing. Some of these serve to regenerate the AHL precursors methionine and S -adenosyl-methionine and to degrade adenosine via inosine and hypoxanthine. The fact that a significant percentage of clinical and environmental isolates of P. aeruginosa is defective for QS because of mutation in the major QS regulatory gene lasR , raises the question of whether the QS machinery can have a negative impact on the organism's fitness. In vitro, lasR mutants have a higher probability to escape lytic death in stationary phase under alkaline conditions than has the QS-proficient wild type. Similar selective forces might also operate in natural environments.}, address = {Institute of Infection, Immunity, and Inflammation, Centre for Biomolecular Sciences, Nottingham University, Nottingham NG7 2RD, UK.}, author = {Heurlier, K. and Denervaud, V. and Haas, D.}, citeulike-article-id = {1940604}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.ijmm.2006.01.043}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1438422106000440}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16503417}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16503417}, day = {06}, doi = {10.1016/j.ijmm.2006.01.043}, issn = {14384221}, journal = {International Journal of Medical Microbiology}, month = {April}, number = {2-3}, pages = {93--102}, posted-at = {2009-10-01 02:51:19}, priority = {2}, title = {Impact of quorum sensing on fitness of Pseudomonas aeruginosa}, url = {http://dx.doi.org/10.1016/j.ijmm.2006.01.043}, volume = {296}, year = {2006} }

TY - JOUR ID - citeulike:1940604 L3 - citeulike-article-id:1940604 N2 - In Pseudomonas aeruginosa , cell–cell communication based on N -acyl-homoserine lactone (AHL) signal molecules (termed quorum sensing) is known to control the production of extracellular virulence factors. Hence, in pathogenic interactions with host organisms, the quorum-sensing (QS) machinery can confer a selective advantage on P. aeruginosa . However, as shown by transcriptomic and proteomic studies, many intracellular metabolic functions are also regulated by quorum sensing. Some of these serve to regenerate the AHL precursors methionine and S -adenosyl-methionine and to degrade adenosine via inosine and hypoxanthine. The fact that a significant percentage of clinical and environmental isolates of P. aeruginosa is defective for QS because of mutation in the major QS regulatory gene lasR , raises the question of whether the QS machinery can have a negative impact on the organism's fitness. In vitro, lasR mutants have a higher probability to escape lytic death in stationary phase under alkaline conditions than has the QS-proficient wild type. Similar selective forces might also operate in natural environments. IS - 2-3 JF - International Journal of Medical Microbiology SN - 14384221 AD - Institute of Infection, Immunity, and Inflammation, Centre for Biomolecular Sciences, Nottingham University, Nottingham NG7 2RD, UK. EP - 102 TI - Impact of quorum sensing on fitness of Pseudomonas aeruginosa VL - 296 SP - 93 AU - Heurlier, K AU - Denervaud, V AU - Haas, D PY - 2006/04/06/ UR - http://dx.doi.org/10.1016/j.ijmm.2006.01.043 ER -