The use of inhaled prostacyclin in nitroprusside-resistant pulmonary artery hypertension. Export

@article{citeulike:507411, abstract = {Because nitroprusside NTP infusion used to differentiate between fixed and reversible pulmonary artery hypertension in heart transplant candidates can result in systemic hypotension before reducing pulmonary artery pressures, we observed the effect or inhaled prostacyclin (PGI(2)) on pulmonary artery pressures and transpulmonic gradient (TPG) in patients with NTP-resistant pulmonary artery hypertension. Six patients undergoing evaluation for orthotropic heart transplant (OHTX) with NTP-resistant pulmonary artery hypertension received inhaled PGI(2), with hemodynamic measurements made at baseline, on NTP- and PGI(2) inhaled after returning to baseline. Compared with hemodynamic results with NTP, inhaled PGI(2) caused significant decrease in pulmonary artery systotic pressure, 43.8 +/- 4.8 mm Hg vs 63.2 +/- 2.04 mm Hg (p < 0.001); Mean pulmonary artery pressure, 22.7 +/- 4.18 vs 32.3 +/- 3.39 mm Hg (p < 0.05); and TPG, 11.5 +/- 3.73 vs 17.0 +/- 4.69 mm Hg (p < 0.05), with a 40\% decrease in pulmonary vascular resistance/systemic vascular resistance ratio. We conclude that inhaled PGI(2) has benefit in reversing pulmonary artery hypertension resistant to NTP, in patients undergoing OHTX evaluation which is due to its more selective pulmonary vasodilation.}, address = {LifeLink Transplant Institute, Tampa, Florida 33606, USA.}, author = {Weston, M. W. and Isaac, B. F. and Crain, C.}, citeulike-article-id = {507411}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11744420}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11744420}, issn = {1053-2498}, journal = {J Heart Lung Transplant}, keywords = {hypertension, nitroprusside, prostatyclin, pulmonary}, month = {December}, number = {12}, pages = {1340--1344}, posted-at = {2006-02-17 04:32:32}, priority = {2}, title = {The use of inhaled prostacyclin in nitroprusside-resistant pulmonary artery hypertension.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11744420}, volume = {20}, year = {2001} }

TY - JOUR ID - citeulike:507411 L3 - citeulike-article-id:507411 N2 - Because nitroprusside NTP infusion used to differentiate between fixed and reversible pulmonary artery hypertension in heart transplant candidates can result in systemic hypotension before reducing pulmonary artery pressures, we observed the effect or inhaled prostacyclin (PGI(2)) on pulmonary artery pressures and transpulmonic gradient (TPG) in patients with NTP-resistant pulmonary artery hypertension. Six patients undergoing evaluation for orthotropic heart transplant (OHTX) with NTP-resistant pulmonary artery hypertension received inhaled PGI(2), with hemodynamic measurements made at baseline, on NTP- and PGI(2) inhaled after returning to baseline. Compared with hemodynamic results with NTP, inhaled PGI(2) caused significant decrease in pulmonary artery systotic pressure, 43.8 +/- 4.8 mm Hg vs 63.2 +/- 2.04 mm Hg (p < 0.001); Mean pulmonary artery pressure, 22.7 +/- 4.18 vs 32.3 +/- 3.39 mm Hg (p < 0.05); and TPG, 11.5 +/- 3.73 vs 17.0 +/- 4.69 mm Hg (p < 0.05), with a 40% decrease in pulmonary vascular resistance/systemic vascular resistance ratio. We conclude that inhaled PGI(2) has benefit in reversing pulmonary artery hypertension resistant to NTP, in patients undergoing OHTX evaluation which is due to its more selective pulmonary vasodilation. IS - 12 JF - J Heart Lung Transplant SN - 1053-2498 AD - LifeLink Transplant Institute, Tampa, Florida 33606, USA. EP - 1344 TI - The use of inhaled prostacyclin in nitroprusside-resistant pulmonary artery hypertension. VL - 20 SP - 1340 KW - hypertension KW - nitroprusside KW - prostatyclin KW - pulmonary AU - Weston, MW AU - Isaac, BF AU - Crain, C PY - 2001/12// UR - http://view.ncbi.nlm.nih.gov/pubmed/11744420 ER -