Impact of long-term cyclosporine immunosuppressive therapy on native kidneys versus renal allografts: serial renal function in heart and kidney transplant recipients. Export

@article{citeulike:531884, abstract = {Aggregate analyses of the impact of long-term cyclosporine administration in kidney transplant recipients have reported generally impaired but stable allograft function. In contrast, experience in extrarenal transplantation has suggested that treatment with cyclosporine for periods in excess of 12 months causes a progressive native nephropathy often leading to dialysis dependence. The extent of this apparent discrepancy between native kidneys and renal allografts is the subject of this study, which examines the evolution of renal function in 119 kidney and 100 heart transplant recipients receiving 12 or more months of cyclosporine immunosuppressive therapy administered in uniform protocols by affiliated clinical transplantation programs. The evolution of renal function in both study cohorts was analyzed retrospectively on the basis of serial serum creatinine (Crs) determinations. Assessment of group mean Crs, reciprocal Crs (1/Crs), and slopes of the curves obtained by plotting 1/Crs versus time in individual patients revealed a significant decline of native kidney function over the first 6 posttransplant months in the cardiac allograft group. Thereafter, however, native kidney function stabilized in these patients, and the aggregate trend was suggestive of no further decline in function over a 3- to 4-year follow-up period. Kidney transplant recipients had an aggregate trend of slowly declining allograft function consistent with the effects of chronic immunologic injury. The data were not consistent with a uniform pattern of a progressive, cyclosporine-induced loss of renal function in either cohort. Long-term use of cyclosporine was found to be associated with impaired but generally stable aggregate renal function in both the heart and the kidney transplant cohorts.(ABSTRACT TRUNCATED AT 250 WORDS)}, address = {Texas Heart Institute, St. Luke's Hospital, Houston.}, author = {Lewis, R. M. and Van Buren, C. T. and Radovancevic, B. and Frazier, O. H. and Janney, R. P. and Powers, P. L. and Golden, D. L. and Giannakis, J. G. and Macris, M. P. and Kerman, R. H.}, citeulike-article-id = {531884}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/2007172}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=2007172}, issn = {1053-2498}, journal = {J Heart Lung Transplant}, keywords = {ci, renal, transplant}, number = {1 Pt 1}, pages = {63--70}, posted-at = {2006-03-06 20:08:13}, priority = {0}, title = {Impact of long-term cyclosporine immunosuppressive therapy on native kidneys versus renal allografts: serial renal function in heart and kidney transplant recipients.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/2007172}, volume = {10}, year = {1991} }

TY - JOUR ID - citeulike:531884 L3 - citeulike-article-id:531884 N2 - Aggregate analyses of the impact of long-term cyclosporine administration in kidney transplant recipients have reported generally impaired but stable allograft function. In contrast, experience in extrarenal transplantation has suggested that treatment with cyclosporine for periods in excess of 12 months causes a progressive native nephropathy often leading to dialysis dependence. The extent of this apparent discrepancy between native kidneys and renal allografts is the subject of this study, which examines the evolution of renal function in 119 kidney and 100 heart transplant recipients receiving 12 or more months of cyclosporine immunosuppressive therapy administered in uniform protocols by affiliated clinical transplantation programs. The evolution of renal function in both study cohorts was analyzed retrospectively on the basis of serial serum creatinine (Crs) determinations. Assessment of group mean Crs, reciprocal Crs (1/Crs), and slopes of the curves obtained by plotting 1/Crs versus time in individual patients revealed a significant decline of native kidney function over the first 6 posttransplant months in the cardiac allograft group. Thereafter, however, native kidney function stabilized in these patients, and the aggregate trend was suggestive of no further decline in function over a 3- to 4-year follow-up period. Kidney transplant recipients had an aggregate trend of slowly declining allograft function consistent with the effects of chronic immunologic injury. The data were not consistent with a uniform pattern of a progressive, cyclosporine-induced loss of renal function in either cohort. Long-term use of cyclosporine was found to be associated with impaired but generally stable aggregate renal function in both the heart and the kidney transplant cohorts.(ABSTRACT TRUNCATED AT 250 WORDS) IS - 1 Pt 1 JF - J Heart Lung Transplant SN - 1053-2498 AD - Texas Heart Institute, St. Luke's Hospital, Houston. EP - 70 TI - Impact of long-term cyclosporine immunosuppressive therapy on native kidneys versus renal allografts: serial renal function in heart and kidney transplant recipients. VL - 10 SP - 63 KW - ci KW - renal KW - transplant AU - Lewis, RM AU - Van Buren, CT AU - Radovancevic, B AU - Frazier, OH AU - Janney, RP AU - Powers, PL AU - Golden, DL AU - Giannakis, JG AU - Macris, MP AU - Kerman, RH PY - 1991///b UR - http://view.ncbi.nlm.nih.gov/pubmed/2007172 ER -